ArticleMolecular and cellular biology1993
Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 91 citations in OpenAlex.
- Article
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- miRNA-34c inhibits myoblasts proliferation by targeting YY1.Cell cycle (Georgetown, Tex.) · 2017Article
- YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State.Stem cells (Dayton, Ohio) · 2017Article
- Overexpression of Striated Muscle Activator of Rho Signaling (STARS) Increases C2C12 Skeletal Muscle Cell Differentiation.Frontiers in physiology · 2016Article
- Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation.Circulation research · 2013Article
- Decreased miR-29 suppresses myogenesis in CKD.Journal of the American Society of Nephrology : JASN · 2011Article
- Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer.Skeletal muscle · 2011Article
- KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites.Molecular and cellular biology · 2010Article
- Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes.Molecular and cellular biology · 2008Article
- RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth.The American journal of pathology · 2007Article
- NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes.Molecular and cellular biology · 2007Article
- New role for serum response factor in postnatal skeletal muscle growth and regeneration via the interleukin 4 and insulin-like growth factor 1 pathways.Molecular and cellular biology · 2006Article
- The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.Genes & development · 2004Article
- SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway.Molecular and cellular biology · 2004Article
- Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts.Molecular and cellular biology · 2002Article
- The role of interleukin-1 in the failing heart.Heart failure reviews · 2001Review
- Activation of the skeletal alpha-actin promoter during muscle regeneration.Journal of muscle research and cell motility · 1998Article
- DNA-binding protein Pur alpha and transcription factor YY1 function as transcription activators of the neuron-specific FE65 gene promoter.The Biochemical journal · 1997Article
- Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Regulatory sequences of the M isozyme of the creatine kinase (MCK) gene have been extensively mapped in skeletal muscle, but little is known about the sequences that control cardiac-specific expression. The promoter and enhancer sequences required for MCK gene expression were assayed by the direct injection of plasmid DNA constructs into adult rat cardiac and skeletal muscle. A 700-nucleotide fragment containing the enhancer and promoter of the rabbit MCK gene activated the expression of a downstream reporter gene in both muscle tissues. Deletion of the enhancer significantly decreased expression in skeletal muscle but had no detectable effect on expression in cardiac muscle. Further deletions revealed a CArG sequence motif at position -179 within the promoter that was essential for cardiac-specific expression. The CArG element of the MCK promoter bound to the recombinant serum response factor and YY1, transcription factors which control expression from structurally similar elements in the skeletal actin and c-fos promoters. MCK-CArG-binding activities that were similar or identical to serum response factor and YY1 were also detected in extracts from adult cardiac muscle. These data suggest that the MCK gene is controlled by different regulatory programs in adult cardiac and skeletal muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.