Evidence map›Paper›PMID 8422704›Full record

ArticleClinical & experimental metastasis1993

Expression of annexins on the surfaces of non-metastatic and metastatic human and rodent tumor cells.

T J Yeatman, T V Updyke, M A Kaetzel, J R Dedman, G L Nicolson

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical & experimental metastasis, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
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  5. Clathrin mediates endocytosis of progastrin and activates MAPKs: role of cell surface annexin A2.American journal of physiology. Gastrointestinal and liver physiology · 2012
    Article
  6. Serologic laboratory findings in malignancy.Rheumatic diseases clinics of North America · 2011
    Review
  7. The role of annexin A2 in tumorigenesis and cancer progression.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011
    Article
  8. Article
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  15. Article
  16. Article
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  19. Article
  20. Functional and genetic analysis of annexin VI.Molecular and cellular biochemistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

T J YeatmanDepartment of General Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030.
T V Updyke
M A Kaetzel
J R Dedman
G L Nicolson
The University of Texas MD Anderson Cancer Center · USThe University of Texas at Austin · US

Funding

TUMOR METASTASISR35CA044352 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI NICOLSON, GARTH L · 1987 to 1993
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NCI NIH HHS R35-CA44352
6 · The paper itself

Abstract

Annexins are a large group of calcium-dependent cytoskeletal- and membrane-associated proteins whose properties include cytoskeleton and phospholipid binding and mitotic signal transduction. Although annexin-like molecules have been reported on the external plasma membranes of certain cells, in general they are considered to be cytoplasmic proteins. We report here the heterogenous expression of certain annexins (I-VI) on the external cell surfaces of non-metastatic and metastatic murine (RAW117 large-cell lymphoma), rat (13762NF mammary adenocarcinoma) and some human (KM12 and HT29 colorectal carcinoma) cell lines but not on some other cell lines such as human (A375 and MeWo) and mouse (B16) melanoma. The implication of annexin cell surface expression in the metastatic process is discussed with respect to tumor cell adhesion.

Indexed as

AnimalsAnnexinsCell Adhesion MoleculesFlow CytometryHumansMiceMicroscopy, FluorescenceNeoplasm MetastasisNeoplasm ProteinsRatsTumor Cells, CulturedAnnexinsCell Adhesion MoleculesNeoplasm Proteins

Identifiers

PMID8422704
OpenAlexW2029181794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.