ArticleMammalian genome : official journal of the International Mammalian Genome Society1993
Genetic mapping of the athymic nude (RNU) locus in the rat to a region on chromosome 10.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
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- RNU (Bioengineering (Basel, Switzerland) · 2021Article
- Evaluation of a cell-based osteogenic formulation compliant with good manufacturing practice for use in tissue engineering.Molecular biology reports · 2020Article
- Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice.Stem cell reports · 2015Article
- T cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis.BMC neuroscience · 2015Article
- A deletion in FOXN1 is associated with a syndrome characterized by congenital hypotrichosis and short life expectancy in Birman cats.PloS one · 2015Article
- The human fetal lung xenograft: validation as model of microvascular remodeling in the postglandular lung.Pediatric pulmonology · 2012Article
- Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- A genetic, physical, and comparative map of rat chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- The rat athymic nude (rnu) locus is closely linked to the inducible nitric oxide synthase gene (Nos2).Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- A rat genetic linkage map and comparative maps for mouse or human homologous rat genes.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The nude trait in the rat is transmitted in an autosomal recessive manner and is associated with thymic aplasia, T-cell deficiency, and hairlessness. Congenic rats homozygous for the RNU (Rowett nude) locus are important models in the study of inflammatory disease, tumor growth, and transplant rejection. The RNU locus has not been previously mapped, and the nature of the gene product is unknown. To determine the map location of this gene, a single F344.rnu/rnu (athymic nude congenic Fischer rat) male congenic rat was bred with 3 LEW/N (NIH stock Lewis rat) female rats to produce F1 progeny. Twelve F1 brother-sister breeding pairs were established. Forty-nine phenotypically nude F2 offspring (198 total) were obtained. Linkage analysis done on F2 DNA revealed highly significant cosegregation between the nude phenotype and eight polymorphic markers located on Chromosome (Chr) 10. The tightest linkages were with: MYH3 (embryonic, skeletal myosin heavy chain) and SHBG (sex hormone-binding globulin), giving 2 point lod scores of 20.2, and 20.0, respectively. The map order and map distances, determined by multipoint linkage calculations, were: RR24-(16.1 cM)-MYH3-(3.5 cM)-SHBG-(4.7 cM)-RNU-(11.9 cM)-F16F2-(24.1 cM)-CLATP (citrate lyase ATPase)-(2.4 cM)-ACE (angiotensin converting enzyme)/PPY (pancreatic polypeptide)-(14.1 cM)-RR1023. The position of the RNU locus in the rat corresponds closely with that of the recently reported nu locus in the mouse. This finding suggests that the nude phenotype in the rat and the mouse arise from defects in homologous genes.
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