ArticleProceedings of the National Academy of Sciences of the United States of America1993
Regulation of cysteine-rich intestinal protein by dexamethasone in the neonatal rat.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer.The American journal of pathology · 2011Article
- CRIP homologues maintain apical cytoskeleton to regulate tubule size in C. elegans.Developmental biology · 2008Article
- Article
- Identifying genes for neuron survival and axon outgrowth in Hirudo medicinalis.Journal of anatomy · 2004Review
- Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis.The Biochemical journal · 1999Review
- Differential display of intestinal mRNAs regulated by dietary zinc.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Cloning and initial characterization of the promoter region of the rat cysteine-rich intestinal protein gene.The Biochemical journal · 1994Article
- Purification and properties of rat cysteine-rich intestinal protein.The Biochemical journal · 1994Article
- The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1.The EMBO journal · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cysteine-rich intestinal protein (CRIP) is an intestinal zinc-binding protein containing a single copy of a cysteine-rich domain known as the LIM motif. CRIP mRNA and protein levels increased in the rat small intestine throughout the suckling period, reaching highest levels by the late weanling stage. A similar developmental pattern of CRIP protein levels was also detected by an increase in zinc binding to CRIP-containing HPLC fractions of intestinal cytosol. Administration of the synthetic glucocorticoid hormone dexamethasone to neonates caused the precocious rise of CRIP mRNA and protein. In adult rats, CRIP mRNA levels were not significantly altered by dexamethasone. Maximal CRIP mRNA content was detected in cells from the mid-villus, as confirmed by expression of cryptdin mRNA. In this report we show the glucocorticoid regulation of the LIM motif-containing protein CRIP and suggest that glucocorticoid hormones play a role in developmental regulation of CRIP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.