ArticleProceedings of the National Academy of Sciences of the United States of America1993
Expression of the human neuropeptide tyrosine Y1 receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 90 citations in OpenAlex.
- Fecal microbiota transplantation for irritable bowel syndrome: An intervention for the 21World journal of gastroenterology · 2021Article
- A role for NPY-NPY2R signaling in albuminuric kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Neuropods.Cellular and molecular gastroenterology and hepatology · 2019Review
- Neuropeptide Y receptors: how to get subtype selectivity.Frontiers in endocrinology · 2013Article
- The NPY system and its neural and neuroendocrine regulation of bone.Current osteoporosis reports · 2012Review
- NPY receptors as potential targets for anti-obesity drug development.British journal of pharmacology · 2011Article
- Stimulation of apical Cl⁻/HCO₃⁻(OH⁻) exchanger, SLC26A3 by neuropeptide Y is lipid raft dependent.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Review
- Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.British journal of pharmacology · 2002Article
- Autoradiographical and immunohistochemical analysis of receptor localization in the central nervous system.The Histochemical journal · 1996Review
- The functional investigation of a human adenocarcinoma cell line, stably transfected with the neuropeptide Y Y1 receptor.British journal of pharmacology · 1996Article
- Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves.Journal of anatomy · 1996Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptide tyrosine (NPY) is the predominant peptide in the innervation of many human tissues and is considered to play a role in the regulation of blood flow, gastrointestinal secretion and motility, and renal function. Three NPY receptors have been identified (Y1, Y2, and Y3) and the cDNAs encoding the human Y1 and bovine Y3 receptors have recently been cloned. We have demonstrated the expression of the Y1 receptor subtype in several fetal and adult human tissues, including the colon, kidney, adrenal gland, heart, and placenta. A single transcript was identified (approximately 2.2 kb) and localized in tissue sections by in situ hybridization. In the colon the receptor is expressed in the mucosa and basal glands, as well as the myenteric and submucous plexuses. Y1 receptor mRNA was detected in renal collecting ducts, loop of Henle, and juxtaglomerular apparatus and in the syncytiotrophoblast layer of placental villi. Fetal aorta and adult intramyocardial, colonic, and renal blood vessels also exhibited receptor expression, localized to the intima as well as the media. The distribution of Y1 receptor expression correlates with that of NPY-immunoreactive nerves and the apparent actions of NPY in the intestine, kidney, and heart. Although the placenta is devoid of nerves, an NPY-like transcript was detected in the villous trophoblast layer. The results indicate a tissue-specific regulation of NPY Y1 receptor expression.
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