ArticleProceedings of the National Academy of Sciences of the United States of America1993
Molecular evolution of the myosin family: relationships derived from comparisons of amino acid sequences.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 169 citations in OpenAlex.
- Nonmuscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling.Circulation research · 2026Article
- Sequence Alignment-Based Prediction of Myosin 7A: Structural Implications and Protein Interactions.International journal of molecular sciences · 2024Article
- Expression of smooth muscle-like effectors and core cardiomyocyte regulators in the contractile papillae ofEvoDevo · 2020Article
- The ancient sarcomeric myosins found in specialized muscles.Skeletal muscle · 2019Review
- Evolution of research on cellular motility over five decades.Biophysical reviews · 2018Review
- Smooth muscle-like CaScientific reports · 2018Article
- Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- An evolutionary perspective on cell migration: Digging for the roots of amoeboid motility.The Journal of cell biology · 2017Article
- Article
- Revisiting Myosin Families Through Large-scale Sequence Searches Leads to the Discovery of New Myosins.Evolutionary bioinformatics online · 2016Article
- An invertebrate smooth muscle with striated muscle myosin filaments.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Evolution and classification of myosins, a paneukaryotic whole-genome approach.Genome biology and evolution · 2014Article
- Article
- Independent specialisation of myosin II paralogues in muscle vs. non-muscle functions during early animal evolution: a ctenophore perspective.BMC evolutionary biology · 2012Article
- Structural and functional insights on the Myosin superfamily.Bioinformatics and biology insights · 2012Article
- How are the cellular functions of myosin VI regulated within the cell?Biochemical and biophysical research communications · 2008Review
- Cargo-binding makes a wild-type single-headed myosin-VI move processively.Biophysical journal · 2006Article
- Multiplying myosins.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- A standardized kinesin nomenclature.The Journal of cell biology · 2004Article
- Association of a nonmuscle myosin II with axoplasmic organelles.Molecular biology of the cell · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To examine the evolutionary relationships between members of the myosin family, we have used two different phylogenetic methods, distance matrix and maximum parsimony, to analyze all available myosin head sequences. We find that there are at least three equally divergent classes of myosin, demonstrating that the current classification of myosin into only two classes needs to be reexamined. In the myosin II class, smooth muscle myosin is more closely related to nonmuscle myosin than to striated muscle myosin, implying that smooth muscle and skeletal muscle myosins were independently derived from nonmuscle myosin and suggesting that similarities between these types of muscle are the result of convergent evolution. The grouping of head sequences produced by phylogenetic analysis is consistent with classifications based on enzymology and structural localization and is generally consistent with grouping based on common tail structure elements. This result demonstrates that specific head sequences are tightly coupled to specific tail sequences throughout evolution and challenges the idea that myosin heads are freely interchangeable units whose unique function is determined only by the tail structure to which it is attached.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.