ArticleProceedings of the National Academy of Sciences of the United States of America1993
Phylogenic and ontogenic expression of hepatocellular bile acid transport.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 81 citations in OpenAlex.
- Establishment of metabolism and transport pathways in the rodent and human fetal liver.International journal of molecular sciences · 2013Review
- Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Bile acid transporters.Journal of lipid research · 2009Review
- Regulation of hepatic bile acid transporters Ntcp and Bsep expression.Biochemical pharmacology · 2007Article
- Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Hepatocellular transport proteins and their role in liver disease.World journal of gastroenterology · 2001Review
- Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells.Cytotechnology · 2000Article
- Characteristics of bile salt uptake into skate hepatocytes.The Biochemical journal · 1994Article
- Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.The Journal of clinical investigation · 1994Article
- Constitutive expression of a saturable transport system for non-esterified fatty acids in Xenopus laevis oocytes.The Biochemical journal · 1994Article
- Expression cloning of a rat liver Na(+)-independent organic anion transporter.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The phylogenic and ontogenic expression of mRNA for the Na+/bile acid cotransporter was determined by Northern analysis utilizing a full-length cDNA probe recently cloned from rat liver. mRNA was detected in several mammalian species, including rat, mouse, and man, but could not be found in livers from nonmammalian species, including chicken, turtle, frog, and small skate. When expression of the bile acid transporter in developing rat liver was studied, mRNA was detected between 18 and 21 days of gestation, at the time when Na(+)-dependent bile acid transport is first detected. Two hepatoma cell lines (HTC and HepG2), the latter of which is known to have lost the Na+/bile acid cotransport system, also did not express mRNA for this transporter. Finally, when mRNA from the lower vertebrate (the small skate) was injected into Xenopus oocytes, only a sodium-independent, chloride-dependent transport system for bile acids was expressed, confirming the integrity of the mRNA and consistent with prior functional studies of bile acid transport in this species. These findings establish that the Na+/bile acid cotransport mRNA is first transcribed in mammalian species, a process that is recapitulated late during mammalian fetal development in rat liver, and that this mRNA is lost in dedifferentiated hepatocytes. In contrast, the mRNA for a multispecific Na+/independent organic anion transport system is transcribed earlier in vertebrate evolution.
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