ArticleThe Journal of cell biology1993
Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 94 citations in OpenAlex.
- Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms.Molecular cell · 2024Article
- Correct dosage of X chromosome transcription is controlled by a nuclear pore component.Cell reports · 2021Article
- Article
- Purification and characterization of a recombinant bacteriophytochrome of Xanthomonas oryzae pathovar oryzae.The protein journal · 2011Article
- Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila.PLoS genetics · 2009Article
- Article
- HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors.Molecular and cellular biology · 2007Article
- Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27.Genes & development · 2003Article
- Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Arabidopsis thaliana atrab28: a nuclear targeted protein related to germination and toxic cation tolerance.Plant molecular biology · 2002Article
- Heterochromatin protein 1 is involved in control of telomere elongation in Drosophila melanogaster.Molecular and cellular biology · 2002Article
- The hinge and chromo shadow domain impart distinct targeting of HP1-like proteins.Molecular and cellular biology · 2001Article
- Conservation of heterochromatin protein 1 function.Molecular and cellular biology · 2000Article
- Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential.Molecular and cellular biology · 2000Article
- Heterochromatin protein 1 is required for the normal expression of two heterochromatin genes in Drosophila.Genetics · 2000Article
- Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations.Genetics · 2000Article
- Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.Genetics · 2000Article
- Versatility of conviction: heterochromatin as both a repressor and an activator of transcription.Genetica · 2000Article
- INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.The Journal of cell biology · 1998Article
- Chromatin components as part of a putative transcriptional repressing complex.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila protein HP1 is a 206 amino acid heterochromatin-associated nonhistone chromosomal protein. Based on the characterization of HP1 to date, there are three properties intrinsic to HP1: nuclear localization, heterochromatin binding, and gene silencing. In this work, we have concentrated on the identification of domains responsible for the nuclear localization and heterochromatin binding properties of HP1. We have expressed a series of beta-galactosidase/HP1 fusion proteins in Drosophila embryos and polytene tissue and have used beta-galactosidase enzymatic activity to identify the subcellular localization of each fusion protein. We have identified two functional domains in HP1: a nuclear localization domain of amino acids 152-206 and a heterochromatin binding domain of amino acids 95-206. Both of these functional domains overlap an evolutionarily conserved COOH-terminal region.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.