ArticleProceedings of the National Academy of Sciences of the United States of America1993
O2A progenitor cells transplanted into the neonatal rat brain develop into oligodendrocytes but not astrocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- DNA Methylation Landscape of ReNcell Common Neural Progenitor Cell Lines Reveals Distinct Lineage Bias.Biology · 2026Article
- Characterizing progenitor cells in developing and injured spinal cord: Insights from single-nucleus transcriptomics and lineage tracing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A2B5 Expression in Central Nervous System and Gliomas.International journal of molecular sciences · 2022Review
- Article
- Review
- Role of glia in optic nerve.Progress in retinal and eye research · 2021Review
- Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity.Neural regeneration research · 2020Article
- Origin of Oligodendrocytes in the Vertebrate Optic Nerve: A Review.Neurochemical research · 2018Review
- Efficient Generation of Viral and Integration-Free Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes.Current protocols in stem cell biology · 2016Article
- Review
- Myelin damage and repair in pathologic CNS: challenges and prospects.Frontiers in molecular neuroscience · 2015Review
- Diverse subtypes of astrocytes and their development during corticogenesis.Frontiers in neuroscience · 2015Review
- Role of NG2 expressing cells in addiction: a new approach for an old problem.Frontiers in pharmacology · 2014Review
- Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- A common progenitor for retinal astrocytes and oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
- Stem cells and the origin and propagation of brain tumors.Journal of child neurology · 2008Review
- Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins.BMC developmental biology · 2007Article
- The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Postnatal cerebral cortical multipotent progenitors: regulatory mechanisms and potential role in the development of novel neural regenerative strategies.Brain pathology (Zurich, Switzerland) · 1999Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The differentiation of the bipotential O2A progenitor cell into an oligodendrocyte or a type 2 astrocyte has been well documented in cell cultures of various regions of the central nervous system. The appropriate tools to prove its existence in vivo have been lacking. We report on an in vitro-in vivo approach that combines stable labeling of an enriched population of cultured O2A progenitors by the fluorescent dye fast blue, followed by their transplantation into neonatal rat brains, which allowed us to study the influence of the brain microenvironment on their lineage decision. The grafted cells survived well and 21 days after grafting nearly all were positive for the oligodendroglial marker galactocerebroside. Surprisingly, the fast blue-positive grafted cells did not stain for the astroglial marker glial fibrillary acidic protein. These results indicate that the O2A progenitor's plasticity is restricted by the in vivo environment, resulting in the developmental exclusion of the type 2 astrocyte initially described in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.