ArticleMolecular and cellular biology1993
Identification of a negative element in the human vimentin promoter: modulation by the human T-cell leukemia virus type I Tax protein.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 47 citations in OpenAlex.
- Vimentin as a target for the treatment of COVID-19.BMJ open respiratory research · 2020Article
- Head-to-head antisense transcription and R-loop formation promotes transcriptional activation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The transcriptional repressor ZBP-89 and the lack of Sp1/Sp3, c-Jun and Stat3 are important for the down-regulation of the vimentin gene during C2C12 myogenesis.Differentiation; research in biological diversity · 2009Article
- Promoter-independent regulation of vimentin expression in mammary epithelial cells by val(12)ras and TGFbeta.Experimental cell research · 2007Article
- TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members.Biochimica et biophysica acta · 2007Article
- Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89.Oncogene · 2004Article
- ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1.Nucleic acids research · 2003Article
- Two regulatory elements of similar structure and placed in tandem account for the repressive activity of the first intron of the human apolipoprotein A-II gene.The Biochemical journal · 1996Article
- Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin.British journal of cancer · 1995Article
- AP-1, ETS, and transcriptional silencers regulate retinoic acid-dependent induction of keratin 18 in embryonic cells.Molecular and cellular biology · 1994Article
- Identification of a cell-type-specific transcriptional repressor in the promoter region of the mouse hepatocyte growth factor gene.Molecular and cellular biology · 1994Article
- Multiple silencer elements are involved in regulating the chicken vimentin gene.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vimentin gene is a member of the intermediate filament multigene family and encodes a protein expressed, in vivo, in all mesenchymal derivatives and, in vitro, in cell types of various origin. We have previously demonstrated that the expression of this growth-regulated gene could be trans activated by the 40-kDa Tax protein of HTLV-I (human T-cell leukemia virus type I) and that responsiveness to this viral protein was mediated by the presence of an NF-kappa B binding site located between -241 and -210 bp upstream of the mRNA cap site (A. Lilienbaum, M. Duc Dodon, C. Alexandre, L. Gazzolo, and D. Paulin, J. Virol. 64:256-263, 1990). These previous assays, performed with deletion mutants of the vimentin promoter linked to the chloramphenicol acetyltransferase gene, also revealed the presence of an upstream negative region between -529 and -241 bp. Interestingly, the inhibitory activity exerted by this negative region was overcome after cotransfection of a Tax-expressing plasmid. In this study, we further characterize the vimentin negative element and define the effect of the Tax protein on the inhibitory activity of this element. We first demonstrate that a 187-bp domain (-424 to -237 bp) behaves as a negative region when placed upstream either of the NF-kappa B binding site of vimentin or of a heterologous enhancer such as that present in the desmin gene promoter. The negative effect can be further assigned to a 32-bp element which is indeed shown to repress the basal or induced activity of the NF-kappa B binding site.(ABSTRACT TRUNCATED AT 250 WORDS)
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