ArticleMolecular and cellular biology1993
Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Unravelling the Role of Epigenetic Modifications in Development and Reproduction of Angiosperms: A Critical Appraisal.Frontiers in genetics · 2022Review
- Double-edged sword: The evolutionary consequences of the epigenetic silencing of transposable elements.PLoS genetics · 2020Review
- Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.PLoS biology · 2013Article
- Molecular characterization of a genomic interval with highly uneven recombination distribution on maize chromosome 10 L.Genetica · 2011Article
- Type 2 NF1 deletions are highly unusual by virtue of the absence of nonallelic homologous recombination hotspots and an apparent preference for female mitotic recombination.American journal of human genetics · 2007Article
- Transgenerational changes in the genome stability and methylation in pathogen-infected plants: (virus-induced plant genome instability).Nucleic acids research · 2007Article
- DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1.Molecular and cellular biology · 2005Article
- Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site.Molecular and cellular biology · 2003Article
- Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.The Journal of experimental medicine · 2001Article
- The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Regulation of V(D)J recombination by transcriptional promoters.Molecular and cellular biology · 1999Article
- Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.The Journal of experimental medicine · 1998Article
- Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system.The American journal of pathology · 1998Review
- A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivo.The Journal of experimental medicine · 1998Article
- Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase.Nucleic acids research · 1997Article
- Stability of patch methylation and its impact in regions of transcriptional initiation and elongation.Molecular and cellular biology · 1997Article
- A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate.Molecular and cellular biology · 1995Article
- The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have previously described a line of transgenic mice with multiple head-to-tail copies of an artificial V-J recombination substrate and have shown that the methylation of this transgene is under the control of a dominant strain-specific modifier gene, Ssm-1. When the transgene array is highly methylated, no recombination is detectable, but when it is unmethylated, V-J joining is seen in the spleen, bone marrow, lymph nodes, and Peyer's patches but not in the thymus or nonlymphoid tissues, including brain tissue. Strikingly, in mice with partially methylated transgene arrays, rearrangement preferentially occurs in hypomethylated copies. Therefore, V-J recombination is negatively correlated with methylated DNA sequences. In addition, it appears that recombination occurs randomly between any two recombination signal sequences within the transgene array. This lack of target preference in an unselectable array of identical targets rules out simple mechanisms of one-dimensional tracking of a V(D)J recombinase complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.