ArticleThe Journal of cell biology1993
Induction of neuron-specific tropomyosin mRNAs by nerve growth factor is dependent on morphological differentiation.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- Molecular cloning ofAnimal biotechnology · 2024Article
- Review
- Structural and Functional Peculiarities of Cytoplasmic Tropomyosin Isoforms, the Products ofInternational journal of molecular sciences · 2021Article
- Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury.Journal of molecular histology · 2013Article
- Molecular architecture of muscles in an acoel and its evolutionary implications.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2011Article
- Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle.Molecular biology of the cell · 2009Article
- Specific features of neuronal size and shape are regulated by tropomyosin isoforms.Molecular biology of the cell · 2005Article
- Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Gamma tropomyosin gene products are required for embryonic development.Molecular and cellular biology · 2004Article
- Actin filament-stabilizing protein tropomyosin regulates the size of dendritic fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Specification of actin filament function and molecular composition by tropomyosin isoforms.Molecular biology of the cell · 2003Article
- Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Differential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression.The Journal of cell biology · 1993Article
- Tropomyosin isoform modulation of focal adhesion structure and cell migration.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have examined the expression of brain-specific tropomyosins during neuronal differentiation. Both TmBr-1 and TmBr-3 were shown to be neuron specific. TmBr-1 and TmBr-3 mRNA levels increased during the most active phase of neurite outgrowth in the developing rat cerebellum. In PC12 cells stimulated by nerve growth factor (NGF) to differentiate to the neuronal phenotype, TmBr-1 and TmBr-3 levels increased with an increasing degree of morphological differentiation. Induction of TmBr-1 and TmBr-3 expression only occurred under conditions where PC12 cells were permitted to extend neurites. NGF was unable to maintain levels of TmBr-1 and TmBr-3 with the loss of neuronal phenotype by resuspension of differentiated PC12 cells. The unique cellular expression and regulation in vivo and in vitro of TmBr-1 and TmBr-3 strongly suggests a critical role of these tropomyosins in neuronal microfilament function. The findings reveal that the induction and maintenance of the neuronal tropomyosins is dependent on morphological differentiation and the maintenance of the neuronal phenotype.
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