ArticleJournal of virology1993
Immunodominance of the VP4 neutralization protein of rotavirus in protective natural infections of young children.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses.Journal of virology · 2024Article
- The Challenges and Opportunities of Next-Generation Rotavirus Vaccines: Summary of an Expert Meeting with Vaccine Developers.Viruses · 2022Article
- Whole genome and in-silico analyses of G1P[8] rotavirus strains from pre- and post-vaccination periods in Rwanda.Scientific reports · 2020Article
- Human VP8* mAbs neutralize rotavirus selectively in human intestinal epithelial cells.The Journal of clinical investigation · 2019Article
- Histo-blood group antigens as receptors for rotavirus, new understanding on rotavirus epidemiology and vaccine strategy.Emerging microbes & infections · 2017Review
- Whole genome analyses of G1P[8] rotavirus strains from vaccinated and non-vaccinated South African children presenting with diarrhea.Journal of medical virology · 2015Article
- Resistance to rotavirus infection in adult volunteers challenged with a virulent G1P1A[8] virus correlated with serum immunoglobulin G antibodies to homotypic viral proteins 7 and 4.The Journal of infectious diseases · 2009Article
- Why does the world need another rotavirus vaccine?Therapeutics and clinical risk management · 2008Article
- Heterogeneity and temporal dynamics of evolution of G1 human rotaviruses in a settled population.Journal of virology · 2006Article
- Prevalence of neutralizing antibodies against different rotavirus serotypes in children with severe rotavirus-induced diarrhea and their mothers.Clinical and diagnostic laboratory immunology · 2004Article
- Rotavirus strain diversity in Blantyre, Malawi, from 1997 to 1999.Journal of clinical microbiology · 2001Article
- Heterotypic protection and induction of a broad heterotypic neutralization response by rotavirus-like particles.Journal of virology · 1999Article
- Subunit rotavirus vaccine administered parenterally to rabbits induces active protective immunity.Journal of virology · 1998Article
- In vitro studies on the use of clay, clay minerals and charcoal to adsorb bovine rotavirus and bovine coronavirus.Veterinary microbiology · 1998Article
- Antigenic and genomic diversity of human rotavirus VP4 in two consecutive epidemic seasons in Mexico.Journal of clinical microbiology · 1998Article
- Serotype specificity of the neutralizing-antibody response induced by the individual surface proteins of rotavirus in natural infections of young children.Clinical and diagnostic laboratory immunology · 1998Article
- Antirotavirus immunoglobulin A neutralizes virus in vitro after transcytosis through epithelial cells and protects infant mice from diarrhea.Journal of virology · 1998Article
- Production of reassortant viruses containing human rotavirus VP4 and SA11 VP7 for measuring neutralizing antibody following natural infection.Clinical and diagnostic laboratory immunology · 1997Article
- Quantification of systemic and local immune responses to individual rotavirus proteins during rotavirus infection in mice.Journal of clinical microbiology · 1996Article
- Heterogeneity of VP4 neutralization epitopes among serotype P1A human rotavirus strains.Clinical and diagnostic laboratory immunology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural infection by very similar strains of rotavirus during the 1988-1989 rotavirus season in Cincinnati, Ohio, provided complete protection of young children against subsequent rotavirus illnesses for a period of at least 2 years. Using this limited strain variability, we characterized the association between the titers of antibody to either the VP4 or the VP7 neutralization protein and protection against subsequent rotavirus disease. This was done by using reassortants that contained only one of the two rotavirus neutralization proteins of 89-12, a culture-adapted isolate representative of the protective rotavirus strains. The other neutralization protein in these reassortants was derived from a heterologous rotavirus (WC3 or EDIM) to which the infected subjects made little or no neutralizing antibody (titers, < or = 20). The geometric mean titer (GMT) of antibody to 89-12 in convalescent-phase sera from the 21 subjects analyzed was 2,323. The GMT of antibody to a reassortant (strain WC-4) that contained the VP7 protein of 89-12 and VP4 of WC3 was 387. In contrast, the GMT of antibody to a reassortant (strain EDIM-7) that contained the VP4 protein of 89-12 and the VP7 protein of EDIM was 1,078. Thus, the major neutralization response was directed against VP4 rather than VP7, a finding that has important implications for development of appropriate rotavirus vaccines.
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