ArticleProceedings of the National Academy of Sciences of the United States of America1993
Cloning and expression of a Kv1.2 class delayed rectifier K+ channel from canine colonic smooth muscle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Adiponectin Exerts Peripheral Inhibitory Effects on the Mouse Gastric Smooth Muscle through the AMPK Pathway.International journal of molecular sciences · 2020Article
- Long Noncoding RNA Kcna2 Antisense RNA Contributes to Ventricular Arrhythmias via Silencing Kcna2 in Rats With Congestive Heart Failure.Journal of the American Heart Association · 2017Article
- The Role of Kv1.2 Channel in Electrotaxis Cell Migration.Journal of cellular physiology · 2016Article
- Role of BKBioMed research international · 2016Article
- Targeting ion channels for the treatment of gastrointestinal motility disorders.Therapeutic advances in gastroenterology · 2012Article
- Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra.American journal of physiology. Cell physiology · 2011Article
- Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels.Pulmonary circulation · 2011Article
- Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Regulation of smooth muscle excitation and contraction.Neurogastroenterology and motility · 2008Review
- K+ currents activated by depolarization in cardiac fibroblasts.Biophysical journal · 2005Article
- Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current.The Journal of physiology · 2003Article
- Functional and molecular expression of a voltage-dependent K(+) channel (Kv1.1) in interstitial cells of Cajal.The Journal of physiology · 2001Article
- Voltage-gated K+ currents in freshly isolated myocytes of the pregnant human myometrium.The Journal of physiology · 1999Article
- Identification, cloning and expression of rabbit vascular smooth muscle Kv1.5 and comparison with native delayed rectifier K+ current.The Journal of physiology · 1999Article
- Contribution of delayed rectifier potassium currents to the electrical activity of murine colonic smooth muscle.The Journal of physiology · 1999Article
- Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells.The Journal of clinical investigation · 1997Article
- Angiotensin II activation of protein kinase C decreases delayed rectifier K+ current in rabbit vascular myocytes.The Journal of physiology · 1996Article
- Regulation of smooth muscle delayed rectifier K+ channels by protein kinase A.Pflugers Archiv : European journal of physiology · 1996Article
- Activation of delayed rectifier potassium channels in canine proximal colon by vasoactive intestinal peptide.The Journal of physiology · 1996Article
- Mechanism of inhibition of delayed rectifier K+ current by 4-aminopyridine in rabbit coronary myocytes.The Journal of physiology · 1996Article
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Authors and funding
7 authors.
Funding
Abstract
A cDNA (CSMK1) encoding a delayed rectifier K+ channel of the Kv1.2 class was cloned from canine colonic circular smooth muscle and expressed in Xenopus oocytes. These channels appear to be uniquely expressed in gastrointestinal muscles and may participate in the electrical slow wave activity. Functional expression of CSMK1 in Xenopus oocytes demonstrated a K+ current that activated in a voltage-dependent manner upon depolarization. This current was highly sensitive to 4-aminopyridine (IC50, 74 microM). A low-conductance K+ channel was identified in inside-out patches from oocytes injected with CSMK1. This channel displayed a linear current-voltage relation with a slope conductance of 14 pS. The channels were blocked in a concentration-dependent manner by 4-aminopyridine. Northern blot analysis demonstrated that CSMK1 is expressed in a wide variety of gastrointestinal smooth muscles. Portal vein, renal artery, and uterus do not express CSMK1, suggesting that, among smooth muscles, expression of this K+ channel may be restricted to gastrointestinal smooth muscles. CSMK1 is 91% homologous to RAK, a delayed rectifier K+ channel cloned from rat heart, but displays unique pharmacological properties and tissue distribution.
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