ArticleProceedings of the National Academy of Sciences of the United States of America1993
Chromosome walking on the TCL1 locus involved in T-cell neoplasia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 71 citations in OpenAlex.
- Review
- Review
- T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways.Frontiers in oncology · 2018Article
- Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.Blood · 2014Article
- Article
- Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.Cell cycle (Georgetown, Tex.) · 2009Article
- Article
- Genetics and molecular biology of chronic lymphocytic leukemia.Current treatment options in oncology · 2005Review
- T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Genetic instability of adult T-cell leukemia/lymphoma by comparative genomic hybridization analysis.Journal of clinical immunology · 2002Article
- The role of TCL1 in human T-cell leukemia.Oncogene · 2001Review
- Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data.Journal of biomolecular NMR · 2000Article
- Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia.Oncogene · 2000Article
- Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.Japanese journal of cancer research : Gann · 1998Article
- Solution structure of the recombinant human oncoprotein p13MTCP1.Journal of biomolecular NMR · 1998Article
- Deregulated expression of TCL1 causes T cell leukemia in mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TCL1 locus on chromosome 14 band q32.1 is frequently involved in the chromosomal translocations and inversions with the T-cell receptor genes observed in several T-cell tumors, including T-prolymphocytic leukemias, acute and chronic leukemias associated with the immunodeficiency syndrome ataxia-telangiectasia, and adult T-cell leukemia. All breakpoints cloned in this area have been mapped to 14q32.1, an area distant approximately 10,000 kb from the immunoglobulin heavy-chain gene locus on chromosome 14q band 32.3. Except for two cases of inversion, no physical linkage of the cloned breakpoints has been reported, nor has a gene been identified in this region. Taking advantage of chromosome-walking techniques and of the P1 phage, we cloned and characterized 450 kb of the germ-line TCL1 locus, starting from the breakpoints of two independent T-cell leukemias. We show that all molecular rearrangements characterized so far map to these clones, indicating not only that this region is the target of chromosomal rearrangements occurring in this area but also that both inversion and translocations occur within a 300-kb region in the T-cell leukemias. In the attempt to identify a candidate oncogene responsible for the malignant transformation, a CpG island centromeric to the inversions and to the translocations has been identified. Two probes near the CpG island have detected sequences conserved among species, as well as two transcripts in the K562 human erythroleukemia cell line. On the basis of these data, a model of activation of the putative TCL1 oncogene is suggested.
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