ArticlePflugers Archiv : European journal of physiology1993
A two-step model of secretion control in neuroendocrine cells.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- The changing view of insulin granule mobility: From conveyor belt to signaling hub.Frontiers in endocrinology · 2022Review
- Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and CaeLife · 2021Article
- Acute reversible SERCA blockade facilitates or blocks exocytosis, respectively in mouse or bovine chromaffin cells.Pflugers Archiv : European journal of physiology · 2021Article
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular CaThe Journal of general physiology · 2019Article
- Unraveling the mechanisms of calcium-dependent secretion.The Journal of general physiology · 2019Review
- The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis.The Journal of general physiology · 2018Review
- How does the stimulus define exocytosis in adrenal chromaffin cells?Pflugers Archiv : European journal of physiology · 2018Review
- Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules.The Journal of general physiology · 2017Article
- The quantal catecholamine release from mouse chromaffin cells challenged with repeated ACh pulses is regulated by the mitochondrial NaThe Journal of physiology · 2017Article
- Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla.Respiratory physiology & neurobiology · 2015Review
- Data-driven modeling of synaptic transmission and integration.Progress in molecular biology and translational science · 2014Review
- Function suggests nano-structure: towards a unified theory for secretion rate, a statistical mechanics approach.Journal of the Royal Society, Interface · 2013Article
- Recovery of vesicular storage and release parameters after high frequency stimulation in rat hippocampus.Cognitive neurodynamics · 2013Article
- Synaptic activity slows vesicular replenishment at excitatory synapses of rat hippocampus.Cognitive neurodynamics · 2013Article
- Spike triggered hormone secretion in vasopressin cells; a model investigation of mechanism and heterogeneous population function.PLoS computational biology · 2013Article
- A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion.PLoS computational biology · 2013Article
- Cycling of dense core vesicles involved in somatic exocytosis of serotonin by leech neurons.Frontiers in physiology · 2012Article
- A computational analysis framework for molecular cell dynamics: case-study of exocytosis.PloS one · 2012Article
- Partitioning and Exocytosis of Secretory Granules during Division of PC12 Cells.International journal of cell biology · 2012Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent experiments on a variety of neuroendocrine cells indicate that intense stimuli readily depress the secretory response. The most likely explanation for this depression is that a pool of release-ready granules is depleted. We present a two-step model of secretion that allows one to simulate the dynamics of such a pool for different time courses of free intracellular Ca concentration [Ca2+]i. We derive rate constants of the model from two types of experiment and find that, for the simplest type of model, not only the rate of consumption (exocytosis) but also the rate of vesicle supply to the pool of release-ready granules must be made Ca-dependent. Given these functional dependences a variety of results from the literature can be simulated. In particular, the model predicts the occurrence of secretory depression and augmentation under appropriate conditions.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.