ArticleMolecular and cellular biology1993
A portion of RNA polymerase II molecules has a component essential for stress responses and stress survival.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 125 citations in OpenAlex.
- Structural Characterization of Native RNA Polymerase II Transcription Complexes and Nucleosomes in Drosophila melanogaster.Nature communications · 2026Article
- Spt5's central KOW domains and the Pol II stalk collaborate to regulate chromatin and 3'-end processing in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2026Article
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- The Association of Rpb4 with RNA Polymerase II Depends on CTD Ser5P Phosphatase Rtr1 and Influences mRNA Decay inInternational journal of molecular sciences · 2022Article
- Article
- Rpb9-deficient cells are defective in DNA damage response and require histone H3 acetylation for survival.Scientific reports · 2018Article
- Article
- Using both strands: The fundamental nature of antisense transcription.Bioarchitecture · 2016Article
- Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation.Nucleic acids research · 2014Article
- Rpb4 subunit functions mainly in mRNA synthesis by RNA polymerase II.The Journal of biological chemistry · 2014Article
- Quantitative proteomics demonstrates that the RNA polymerase II subunits Rpb4 and Rpb7 dissociate during transcriptional elongation.Molecular & cellular proteomics : MCP · 2013Article
- The RNA Pol II sub-complex hsRpb4/7 is required for viability of multiple human cell lines.Protein & cell · 2012Article
- Human GTPases associate with RNA polymerase II to mediate its nuclear import.Molecular and cellular biology · 2011Article
- Validation of reference genes for quantitative expression analysis by real-time RT-PCR in Saccharomyces cerevisiae.BMC molecular biology · 2009Article
- Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Modulation of RNA polymerase II subunit composition by ubiquitylation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Archaeal RNA polymerase subunits E and F are not required for transcription in vitro, but a Thermococcus kodakarensis mutant lacking subunit F is temperature-sensitive.Molecular microbiology · 2008Article
- Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins.Eukaryotic cell · 2008Article
- Genomewide recruitment analysis of Rpb4, a subunit of polymerase II in Saccharomyces cerevisiae, reveals its involvement in transcription elongation.Eukaryotic cell · 2008Article
- The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms.The Journal of cell biology · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cells respond to stress by altering gene expression, and these adjustments facilitate stress tolerance. Although transcriptional changes are integral to most stress responses, little is known about the mechanisms that permit the transcription apparatus itself to tolerate stress. Here we report that a major role of the RNA polymerase II subunit RPB4 is to permit appropriate transcriptional responses during stress. Yeast cells lacking RPB4 have essentially wild-type growth rates at moderate temperatures (18 to 22 degrees C), but their growth rates are substantially reduced at temperatures outside this range. When subjected to a heat shock, cells lacking RPB4 rapidly lose the ability to transcribe genes and experience a dramatic loss in viability. When cells lacking RPB4 are subjected to the nutrient stress that accompanies entry into stationary phase, they also exhibit a substantial decline in mRNA synthesis and in viability relative to wild-type cells. Interestingly, the portion of RNA polymerase II molecules that contain RPB4 is small in log phase but increases substantially as cells enter stationary phase. We propose that the association of RPB4 with the other RNA polymerase II subunits increases the tolerance of the enzyme to stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.