ArticleMolecular and cellular biology1993
Nonrandom localization of recombination events in human alpha satellite repeat unit variants: implications for higher-order structural characteristics within centromeric heterochromatin.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 76 citations in OpenAlex.
- Pangenome obtained by long-read sequencing of 11 genomes reveal hidden functional structural variants in pigs.iScience · 2023Article
- A draft genome of Drung cattle reveals clues to its chromosomal fusion and environmental adaptation.Communications biology · 2022Article
- High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote.Scientific reports · 2022Article
- The time is ripe to investigate human centromeres by long-read sequencing†.DNA research : an international journal for rapid publication of reports on genes and genomes · 2021Article
- Hotspots of Human Mutation.Trends in genetics : TIG · 2021Review
- Rapid and ongoing evolution of repetitive sequence structures in human centromeres.Science advances · 2020Article
- Genomic and functional variation of human centromeres.Experimental cell research · 2020Review
- Review
- Alpha satellite DNA biology: finding function in the recesses of the genome.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Review
- α satellite DNA variation and function of the human centromere.Nucleus (Austin, Tex.) · 2017Article
- Adjacent sequences disclose potential for intra-genomic dispersal of satellite DNA repeats and suggest a complex network with transposable elements.BMC genomics · 2016Article
- Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.Genome research · 2016Article
- Ancestral Y-linked genes were maintained by translocation to the X and Y chromosomes fused to an autosomal pair in the Okinawa spiny rat Tokudaia muenninki.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Alpha-CENTAURI: assessing novel centromeric repeat sequence variation with long read sequencing.Bioinformatics (Oxford, England) · 2016Article
- Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans.Genome biology · 2015Article
- A unique chromatin complex occupies young α-satellite arrays of human centromeres.Science advances · 2015Article
- Neocentromeres: a place for everything and everything in its place.Trends in genetics : TIG · 2014Review
- HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses.Genome research · 2013Article
- Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution.Genome biology · 2013Article
- Conserved DNA Motifs, Including the CENP-B Box-like, Are Possible Promoters of Satellite DNA Array Rearrangements in Nematodes.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Tandemly repeated DNA families appear to undergo concerted evolution, such that repeat units within a species have a higher degree of sequence similarity than repeat units from even closely related species. While intraspecies homogenization of repeat units can be explained satisfactorily by repeated rounds of genetic exchange processes such as unequal crossing over and/or gene conversion, the parameters controlling these processes remain largely unknown. Alpha satellite DNA is a noncoding tandemly repeated DNA family found at the centromeres of all human and primate chromosomes. We have used sequence analysis to investigate the molecular basis of 13 variant alpha satellite repeat units, allowing comparison of multiple independent recombination events in closely related DNA sequences. The distribution of these events within the 171-bp monomer is nonrandom and clusters in a distinct 20- to 25-bp region, suggesting possible effects of primary sequence and/or chromatin structure. The position of these recombination events may be associated with the location within the higher-order repeat unit of the binding site for the centromere-specific protein CENP-B. These studies have implications for the molecular nature of genetic recombination, mechanisms of concerted evolution, and higher-order structure of centromeric heterochromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.