ArticleMolecular and cellular biology1993
The MEF-3 motif is required for MEF-2-mediated skeletal muscle-specific induction of the rat aldolase A gene.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells.EMBO molecular medicine · 2024Article
- Is the secret of VDAC Isoforms in their gene regulation? Characterization of humanInternational journal of molecular sciences · 2020Article
- Integrating genome and transcriptome profiling for elucidating the mechanism of muscle growth and lipid deposition in Pekin ducks.Scientific reports · 2017Article
- Regional Differences of Proteins Expressing in Adipose Depots Isolated from Cows, Steers and Bulls as Identified by a Proteomic Approach.Asian-Australasian journal of animal sciences · 2016Article
- Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep.BMC genomics · 2011Article
- Identification of novel transcripts from the porcine MYL1 gene and initial characterization of its promoters.Molecular and cellular biochemistry · 2010Article
- Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer.Molecular and cellular biology · 2004Article
- Molecular dissection of DNA sequences and factors involved in slow muscle-specific transcription.Molecular and cellular biology · 2001Article
- Functional analysis of the homeodomain protein SIX5.Nucleic acids research · 2000Article
- Myogenin induces a shift of enzyme activity from glycolytic to oxidative metabolism in muscles of transgenic mice.The Journal of cell biology · 1999Article
- The myogenic regulatory circuit that controls cardiac/slow twitch troponin C gene transcription in skeletal muscle involves E-box, MEF-2, and MEF-3 motifs.Gene expression · 1999Article
- Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements.Molecular and cellular biology · 1999Article
- Tissue-restricted expression of the cardiac alpha-myosin heavy chain gene is controlled by a downstream repressor element containing a palindrome of two ets-binding sites.Molecular and cellular biology · 1998Article
- Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A combination of MEF3 and NFI proteins activates transcription in a subset of fast-twitch muscles.Molecular and cellular biology · 1997Article
- Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Common core sequences are found in skeletal muscle slow- and fast-fiber-type-specific regulatory elements.Molecular and cellular biology · 1996Article
- Quantitative discrimination of MEF2 sites.Molecular and cellular biology · 1996Article
- Fast-muscle-specific DNA-protein interactions occurring in vivo at the human aldolase A M promoter are necessary for correct promoter activity in transgenic mice.Molecular and cellular biology · 1996Article
- Transcription of the human beta enolase gene (ENO-3) is regulated by an intronic muscle-specific enhancer that binds myocyte-specific enhancer factor 2 proteins and ubiquitous G-rich-box binding factors.Molecular and cellular biology · 1995Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The rat aldolase A gene contains two alternative promoters and two alternative first exons. The distal promoter M is expressed at a high level only in skeletal muscle. Previous in vitro transfection studies identified the region from -202 to -85 as an enhancer that is responsible for dramatic activation during the differentiation of chicken primary myoblasts. This enhancer contains an A/T-rich sequence resembling the MEF-2 motif, which is an important element of muscle enhancers and promoters. In this study, we demonstrate that the MEF-2 sequence is essential but not sufficient for the activity of the enhancer. Another region required for the activity was recognized by a nuclear factor, tentatively named MAF1. MAF1 was found in both muscle cells and nonmuscle cells, and MAF1 from both cell types was indistinguishable by gel retardation and DNase I footprint experiments. The sequence required for MAF1 binding is very similar to the MEF-3 motif, which is an element of the skeletal muscle-specific enhancer of the cardiac troponin C gene. Because MAF1 and MEF-3 are closely related in both recognition sequence and distribution, MAF1 and MEF-3 probably represent the same nuclear factor which may play an important role in muscle gene transcription. Thus, the muscle-specific induction of the aldolase A gene is governed by muscle-specific MEF-2 and existing MEF-3 (MAF1).
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