ArticleMolecular and cellular biology1993
Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3' enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.Antioxidants & redox signaling · 2011Review
- Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage.Current hypertension reports · 2010Article
- MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival.The Journal of biological chemistry · 2005Article
- Endothelin-1 induces phosphorylation of GATA-4 transcription factor in the HL-1 atrial-muscle cell line.The Biochemical journal · 2001Article
- Ets target genes: past, present and future.Oncogene · 2000Review
- Structure and activity of mouse S-adenosylmethionine decarboxylase gene promoters and properties of the encoded proteins.The Biochemical journal · 1998Article
- The human neuronal alpha 1-chimaerin gene contains a position-dependent negative regulatory element in the first exon.Neurochemical research · 1996Article
- Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer.Nucleic acids research · 1995Article
- Identification and characterization of a neuroretina-specific enhancer element in the quail Pax-6 (Pax-QNR) gene.Molecular and cellular biology · 1995Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear run-on experiments have shown that the high level of expression of the mouse cytosolic glutathione peroxidase mRNA in erythroid cells is due to up-regulation of the gene at the transcriptional level. Studies of the chromatin structure around the cytosolic glutathione peroxidase gene have revealed a series of DNase I hypersensitive sites (DHSS) in the 3' flanking region of the gene in erythroid and other high-expression tissues that are lacking in low-expression cells, in addition to a DHSS over the promoter region in both high- and low-expression tissues. Functional transfection experiments have demonstrated that one of the 3' DHSS regions functions as an enhancer in erythroid cells but not in a low-expression epithelial cell line; and site-directed mutagenesis and footprinting experiments reveal that the activity of the erythroid cell-specific enhancer requires a cluster of binding sites for the CACC/GT box factors and the GATA and Ets families of transcription factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.