ArticleMolecular and cellular biology1993
Expression of bovine myf5 induces ectopic skeletal muscle formation in transgenic mice.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease.Heart failure reviews · 2016Review
- Direct Cardiac Reprogramming: Advances in Cardiac Regeneration.BioMed research international · 2015Review
- Pitx2c is reactivated in the failing myocardium and stimulates myf5 expression in cultured cardiomyocytes.PloS one · 2014Article
- Mechanisms of muscle gene regulation in the electric organ of Sternopygus macrurus.The Journal of experimental biology · 2013Article
- Expressed sequence tags for bovine muscle satellite cells, myotube formed-cells and adipocyte-like cells.PloS one · 2013Article
- miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors.The Journal of cell biology · 2011Article
- Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD.The Journal of clinical investigation · 1996Article
- Overexpression of myogenin in muscles of transgenic mice: interaction with Id-1, negative crossregulation of myogenic factors, and induction of extrasynaptic acetylcholine receptor expression.Molecular and cellular biology · 1995Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
myf5 is one of a family of four myogenic determination genes that control skeletal muscle differentiation. To study the role of myf5 in vivo, we generated transgenic mice harboring the bovine homolog, bmyf, under control of the murine sarcoma virus promoter. Ectopic expression of the full-length bmyf transgene was detected in brain and heart tissue samples of F1 progeny from transgenic founder mice. Ectopic bmyf expression activated endogenous skeletal myogenic determination genes in the hearts and brains of transgenic animals. Incomplete skeletal myogenesis in most hearts gave rise to cardiomegaly and focal areas of cardiomyopathy. In brains in which ectopic expression led to a more complete myogenesis, focal areas of multinucleated, striated myotubes containing actin, desmin, and myosin were observed. These unexpected results show that myf5 can initiate myogenic differentiation in vivo, supporting the hypothesis that myf5 is responsible for determination of cells to the myogenic lineage in normal embryogenesis.
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