ArticleMolecular & general genetics : MGG1993
MSI3, a multicopy suppressor of mutants hyperactivated in the RAS-cAMP pathway, encodes a novel HSP70 protein of Saccharomyces cerevisiae.
Article in Molecular & general genetics : MGG, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 50 citations in OpenAlex.
- Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo.G3 (Bethesda, Md.) · 2013Article
- The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.Molecular and cellular biology · 2010Article
- The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding.FEBS letters · 2008Article
- The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD).The Journal of biological chemistry · 2007Article
- Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1.Biochemistry · 2006Article
- Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development.Molecular and cellular biology · 2006Article
- Article
- Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast.Molecular biology of the cell · 2004Article
- Overexpression of yeast Hsp110 homolog Sse1p suppresses ydj1-151 thermosensitivity and restores Hsp90-dependent activity.Molecular biology of the cell · 2002Article
- The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s.Cell stress & chaperones · 2000Review
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
- The refolding activity of the yeast heat shock proteins Ssa1 and Ssa2 defines their role in protein translocation.The Journal of cell biology · 1996Article
- Members of the Hsp70 family of proteins in the cell wall of Saccharomyces cerevisiae.Journal of bacteriology · 1996Article
- A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors.The EMBO journal · 1996Article
- A heat shock transcription factor with reduced activity suppresses a yeast HSP70 mutant.Molecular and cellular biology · 1995Article
- A dominant interfering mutation in RAS1 of Saccharomyces cerevisiae.Molecular & general genetics : MGG · 1993Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The MSI3 gene was isolated as a multicopy suppressor of the heat shock-sensitive phenotype of the ira1 mutation, which causes hyperactivation of the RAS-cAMP pathway. Overexpression of MSI3 also suppresses the heat shock-sensitive phenotype of the bcy1 mutant. Determination of the DNA sequence of MSI3 revealed that MSI3 can encode a 77.4 kDa protein related to the HSP70 family. The amino acid sequence of Msi3p is about 30% identical to that of the Ssa1p of Saccharomyces cerevisiae. This contrasts with the finding that members of the HSP70 family generally show at least 50% amino acid identity. The consensus nucleotide sequence of the heat shock element (HSE) was found in the upstream region of MSI3. Moreover, the steady-state levels of the MSI3 mRNA and protein were increased upon heat shock. These results indicate that the MSI3 gene encodes a novel HSP70-like heat shock protein. Disruption of the MSI3 gene was associated with a temperature sensitive growth phenotype but unexpectedly, thermotolerance was enhanced in the disruptant.
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