ArticleJournal of molecular evolution1993
A model for the mechanism of initial generation of short interspersed elements (SINEs).
Article in Journal of molecular evolution, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Comparative genomics reveals LINE-1 recombination with diverse RNAs.Cell genomics · 2026Article
- Retrotransposon targeting to RNA polymerase III-transcribed genes.Mobile DNA · 2018Review
- Identification of a recently active mammalian SINE derived from ribosomal RNA.Genome biology and evolution · 2015Article
- An ancient repeat sequence in the ATP synthase beta-subunit gene of forcipulate sea stars.Journal of molecular evolution · 2007Article
- Can SINEs: a family of tRNA-derived retroposons specific to the superfamily Canoidea.Nucleic acids research · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most animal genomes contain a large number of short interspersed elements (SINEs) that have a composite structure and contain a region that is homologous to a tRNA. The majority of SINEs have been found to be derived from a tRNA(Lys), being categorized as members of a superfamily of tRNA(Lys)-related SINEs. The consensus sequences of five SINEs that belong to this superfamily were aligned. It was found that, in the tRNA-unrelated region, there are two sequence motifs that are almost identical among these five SINEs and are at a distance of 10-11 nucleotides from each other. This observation suggests a common evolutionary origin of these SINEs and/or some function(s) for these motifs. Similar sequences were unexpectedly found to be present in the sequences complementary to the U5 regions of several mammalian retroviruses whose primer is a tRNA(Lys). On the basis of these findings, we propose a possible model for the generation of SINEs whereby they are derived from a "strong stop DNA" with a primer tRNA that is an intermediate in the process of reverse transcription of certain retroviruses.
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