ArticleJournal of medical genetics1993
Exclusion of candidate genes from a role in cleft lip with or without cleft palate: linkage and association studies.
Article in Journal of medical genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 56 citations in OpenAlex.
- An integrative, genomic, transcriptomic and network-assisted study to identify genes associated with human cleft lip with or without cleft palate.BMC medical genomics · 2020Article
- Review
- Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate.Frontiers in genetics · 2016Article
- Autosomal dominant nonsyndromic cleft lip and palate: significant evidence of linkage at 18q21.1.American journal of human genetics · 2007Article
- Genetics of cleft lip and palate : a review.The Malaysian journal of medical sciences : MJMS · 2007Article
- Evidence for an association between nonsyndromic cleft lip with or without cleft palate and a gene located on the long arm of chromosome 4.American journal of human genetics · 1995Article
- Face facts: genes, environment, and clefts.American journal of human genetics · 1995Article
- The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Exclusion of retinoic acid receptor and a cartilage matrix protein in non-syndromic CL(P) families.Journal of medical genetics · 1995Article
- Microsatellite-based fine mapping of the Van der Woude syndrome locus to an interval of 4.1 cM between D1S245 and D1S414.American journal of human genetics · 1995Article
- Exclusion of the cartilage link protein and the cartilage matrix protein genes as the mutant loci in several heritable chondrodysplasias.Human genetics · 1994Article
- Interpreting the evidence for an association between the retinoic acid receptor locus and non-syndromic cleft lip with or without cleft palate.Journal of medical genetics · 1994Article
- Current concepts in genetics of nonsyndromic clefts.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of IndiaArticle
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5 authors.
Funding
Abstract
Candidate genes and marker loci for cleft lip/palate (CL/P) were tested using linkage analyses and association studies. Eight British families with apparent autosomal dominant inheritance of non-syndromic CL/P participated in the linkage analyses while the association analyses involved 61 unrelated British white people with CL/P and 60 controls. The report of an association between RARA (17q21) and unrelated Australian persons with CL/P (p = 0.016) was not confirmed in British CL/P persons (chi 2 = 0.954, p > 0.1). There was also no evidence of linkage between RARA and the eight CL/P families (Z = -3.211, theta = 0.001). Linkage was excluded between familial CL/P and F13A1 (map position 6p24-25) with an observed maximum lod score of Z = -2.052 at theta = 0.05. No association was found between alleles at VIM (10p13) and the British CL/P subjects (chi 2 = 0.110, p > 0.5). Multipoint analysis excluded linkage between familial CL/P and the markers D1S65 and D1S58 which flank the Van der Woude syndrome locus with a maximum lod score of Z = -4.0. This suggests that the genetic defect underlying VWS is not the same as in non-syndromic CL/P. There was no evidence of linkage between CRTL1 (5q15) and the eight CL/P families (Z = -3.466, theta = 0.05).
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