ArticleThe Journal of physiology1993
cAMP-activated chloride currents in amphibian retinal pigment epithelial cells.
Article in The Journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Mouse retinal pigment epithelial cells exhibit a thiocyanate-selective conductance.American journal of physiology. Cell physiology · 2018Article
- Functional abnormalities in the retinal pigment epithelium of CFTR mutant mice.Experimental eye research · 2006Article
- Chloride currents in acutely isolated Xenopus retinal pigment epithelial cells.The Journal of physiology · 2003Article
- Purinergic regulation of cation conductances and intracellular Ca2+ in cultured rat retinal pigment epithelial cells.The Journal of physiology · 1999Article
- Swelling- and cAMP-activated Cl- currents in isolated rat carotid body type I cells.The Journal of physiology · 1997Article
- A cyclic GMP-dependent housekeeping Cl- channel in rabbit gastric parietal cells activated by a vasodilator ecabapide.British journal of pharmacology · 1996Article
- Activation of cardiac chloride conductance by the tyrosine kinase inhibitor, genistein.British journal of pharmacology · 1996Article
- Activation of a Cl- conductance by SCN- in single proximal tubule cells isolated from Rana temporaria.The Journal of physiology · 1995Article
- A cyclic adenosine monophosphate agonist elevates the b- and c-waves of the rabbit direct-current electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 1995Article
- Role of cyclic AMP-induced Cl conductance in aqueous humour formation by the dog ciliary epithelium.British journal of pharmacology · 1994Article
- Action of niflumic acid on evoked and spontaneous calcium-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein.British journal of pharmacology · 1994Article
- Regulation of the retinal interphotoreceptor matrix Na by the retinal pigment epithelium during the light response.Experientia · 1994Article
- Properties of the inwardly rectifying K+ conductance in the toad retinal pigment epithelium.The Journal of physiology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. The effect of cAMP on whole-cell currents in isolated retinal pigment epithelial (RPE) cells of the bullfrog and marine toad was investigated by means of the perforated patch clamp technique. 2. Superfusing cells with either cAMP or forskolin led to the development of a time-independent current that had a linear current-voltage (I-V) relationship. The reversal potential of (Vrev) of the cAMP-activated current was unaffected by the removal of either Na+ or HCO3- from the external and internal solutions or by the addition of extracellular barium, but it was near the Cl- equilibrium potential (ECl) over a wide range of extracellular Cl- concentrations, suggesting the presence of a Cl(-)-selective channel. 3. The anion permeability sequence of the cAMP-activated conductance calculated from biionic reversal potentials was NO3- = I- > Br- > Cl- >> HCO3- > methanesulphonate. 4. The conductance was blocked by a variety of Cl- transport inhibitors, including 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS), 4,4'-dinitro-2,2'- stilbene disulphonic acid (DNDS), frusemide, N-phenylanthranilic acid (DPC) and niflumic acid. 5. The present study demonstrates that cAMP activates a Cl(-)-selective channel that most probably resides in the basolateral membrane.
Indexed as
Identifiers
8410715PMC1175501W1550371055What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.