ArticleThe Journal of cell biology1993
Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed.
- Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in Cancer.Frontiers in genetics · 2021Review
- T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development.Frontiers in cell and developmental biology · 2021Review
- Two is a Crowd: Two is a Crowd: On the Enigmatic Etiopathogenesis of Conjoined Twinning.Clinical anatomy (New York, N.Y.) · 2019Review
- Article
- RAPGEF5 Regulates Nuclear Translocation of β-Catenin.Developmental cell · 2018Article
- The role of adherens junctions in the developing neocortex.Cell adhesion & migration · 2015Review
- Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.PLoS biology · 2014Article
- GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.PloS one · 2013Article
- Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling.Progress in molecular biology and translational science · 2013Review
- Article
- Three decades of Wnts: a personal perspective on how a scientific field developed.The EMBO journal · 2012Review
- Wnt signaling: the β-cat(enin)'s meow.Genes & development · 2012Article
- Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members.Journal of cell science · 2010Article
- Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest.Development (Cambridge, England) · 2010Article
- Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL.Nature cell biology · 2008Article
- R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.BMC developmental biology · 2008Article
- E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions.Molecular biology of the cell · 2007Article
- Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane.The Journal of cell biology · 2005Article
- Temporally distinct demands for classic cadherins in synapse formation and maturation.Molecular and cellular neurosciences · 2004Article
- Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes.The Journal of cell biology · 2004Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We have obtained evidence that a known intracellular component of the cadherin cell-cell adhesion machinery, beta-catenin, contributes to the development of the body axis in the frog Xenopus laevis. Vertebrate beta-catenin is homologous to the Drosophila segment polarity gene product armadillo, and to vertebrate plakoglobin (McCrea, P. D., C. W. Turck, and B. Gumbiner. 1991. Science (Wash. DC). 254: 1359-1361.). Beta-Catenin was found present in all Xenopus embryonic stages examined, and associated with C-cadherin, the major cadherin present in early Xenopus embryos. To test beta-catenin's function, affinity purified Fab fragments were injected into ventral blastomeres of developing four-cell Xenopus embryos. A dramatic phenotype, the duplication of the dorsoanterior embryonic axis, was observed. Furthermore, Fab injections were capable of rescuing dorsal features in UV-ventralized embryos. Similar phenotypes have been observed in misexpression studies of the Wnt and other gene products, suggesting that beta-catenin participates in a signaling pathway which specifies embryonic patterning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.