ArticleJournal of bacteriology1993
A growth rate-limiting process in the last growth phase of the yeast life cycle involves RPB4, a subunit of RNA polymerase II.
Article in Journal of bacteriology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Reorganization of budding yeast cytoplasm upon energy depletion.Molecular biology of the cell · 2020Article
- Article
- The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms.The Journal of cell biology · 2007Article
- Nucleocytoplasmic shuttling of the Rpb4p and Rpb7p subunits of Saccharomyces cerevisiae RNA polymerase II by two pathways.Eukaryotic cell · 2006Article
- Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae.Molecular biology of the cell · 2004Article
- Domainal organization of the lower eukaryotic homologs of the yeast RNA polymerase II core subunit Rpb7 reflects functional conservation.Nucleic acids research · 2004Article
- Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.The EMBO journal · 2003Article
- Structural and functional homology between the RNAP(I) subunits A14/A43 and the archaeal RNAP subunits E/F.Nucleic acids research · 2003Article
- Rpb4p, a subunit of RNA polymerase II, mediates mRNA export during stress.Molecular biology of the cell · 2003Article
- An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP.Molecular and cellular biology · 2003Article
- Eukaryotic translation initiation factor 4E-dependent translation is not essential for survival of starved yeast cells.Journal of bacteriology · 2001Article
- The Rpb4 subunit of fission yeast Schizosaccharomyces pombe RNA polymerase II is essential for cell viability and similar in structure to the corresponding subunits of higher eukaryotes.Molecular and cellular biology · 1999Article
- Rpb7 can interact with RNA polymerase II and support transcription during some stresses independently of Rpb4.Molecular and cellular biology · 1999Article
- Rpb4, a subunit of RNA polymerase II, enables the enzyme to transcribe at temperature extremes in vitro.Journal of bacteriology · 1998Article
- Analysis of the interaction of the novel RNA polymerase II (pol II) subunit hsRPB4 with its partner hsRPB7 and with pol II.Molecular and cellular biology · 1998Article
- A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family.Journal of bacteriology · 1996Article
- Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology.Molecular biology of the cell · 1995Article
- Protein synthesis in long-term stationary-phase cultures of Saccharomyces cerevisiae.Journal of bacteriology · 1994Article
- A portion of RNA polymerase II molecules has a component essential for stress responses and stress survival.Molecular and cellular biology · 1993Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saccharomyces cerevisiae cells, grown on a fermentable carbon source, display two growth phases before they enter the stationary phase: a rapid phase (log phase) followed by a slow phase. It was previously shown that a subunit of the yeast RNA polymerase II, RPB4, positively affects the activity of the enzyme in post-log phases but has little or no effect on its activity in log phase. Here, I show that RPB4 level limits the growth rate during the slow growth phase. Thus, a small increase in RPB4 protein level, in cells carrying multiple copies of the RPB4 gene, results in an almost twofold increase in the growth rate during this phase. Furthermore, RPB4 expression is differentially regulated in the two growth phases. During the slow growth phase, a posttranscriptional process which controls the RPB4 level and thus can control growth rate becomes active. These results reveal a complex growth control mechanism, in which the transcriptional apparatus is probably a limiting element, operating in the last stages of the yeast growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.