ArticleJapanese journal of cancer research : Gann1993
Expression of amphiregulin, a novel gene of the epidermal growth factor family, in human gastric carcinomas.
Article in Japanese journal of cancer research : Gann, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.Journal of cancer research and clinical oncology · 2017Article
- Article
- Mesenchymal Stem Cells Shed Amphiregulin at the Surface of Lung Carcinoma Cells in a Juxtacrine Manner.Neoplasia (New York, N.Y.) · 2015Article
- Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer.Cancer science · 2012Article
- Gene expression profiling in a mouse model of Helicobacter-induced gastric cancer.Cancer science · 2007Article
- Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.Oncogene · 2006Article
- Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777.Digestive diseases and sciences · 2006Article
- Expression of Cbl linking with the epidermal growth factor receptor system is associated with tumor progression and poor prognosis of human gastric carcinoma.Virchows Archiv : an international journal of pathology · 2004Article
- Expression of interleukin-8 correlates with vascularity in human gastric carcinomas.The American journal of pathology · 1998Article
- Immunohistochemical studies on EGF family growth factors in normal and ulcerated human gastric mucosa.Digestive diseases and sciences · 1997Article
- Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis.Clinical & experimental metastasis · 1997Article
- The role of amphiregulin in breast cancer.Breast cancer research and treatment · 1995Review
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Authors and funding
9 authors at 2 institutions in 2 countries.
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Abstract
The expression of mRNA for amphiregulin (AR), a novel gene of the epidermal growth factor family, was examined in 8 human gastric carcinoma cell lines and 32 gastric carcinoma tissues as well as corresponding normal mucosa. Of the 8 gastric carcinoma cell lines, 7 expressed 1.4 kb AR mRNA at various levels. The expression of AR mRNA by TMK-1 and MKN-28 cells was increased by treatment with epidermal growth factor or transforming growth factor a. In surgical cases, all the gastric carcinoma tissues and their adjacent normal mucosa expressed AR mRNA. Interestingly, 20 (62.5%) out of 32 tumors expressed AR mRNA at higher levels than their corresponding normal mucosas (tumor/normal > or = 1.2). No obvious correlation was observed between the AR mRNA levels and the histological types or tumor staging of gastric carcinoma. Immunohistochemically, AR protein was localized to the cytoplasm and/or nucleus in tumor cells. These results suggest that AR produced by tumor cells may be involved in the pathogenesis and/or progression of human gastric carcinoma.
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