ReviewThe Histochemical journal1993
Integrins: cell adhesives and modulators of cell function.
Review in The Histochemical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Engagement of αFrontiers in microbiology · 2024Article
- Molecular and cellular mechanisms controlling integrin-mediated cell adhesion and tumor progression in ovarian cancer metastasis: a review.Clinical & experimental metastasis · 2022Review
- Article
- Bacterial induction of Snail1 contributes to blood-brain barrier disruption.The Journal of clinical investigation · 2015Article
- Article
- Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration.Nature communications · 2011Article
- Culture of K562 human myeloid leukemia cells in presence of fibronectin expresses and secretes MMP-9 in serum-free culture medium.International journal of clinical and experimental pathology · 2010Article
- Helicobacter pylori usurps cell polarity to turn the cell surface into a replicative niche.PLoS pathogens · 2009Article
- A model for sequestration of the transmission stages of Plasmodium falciparum: adhesion of gametocyte-infected erythrocytes to human bone marrow cells.Infection and immunity · 2000Article
- Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers.Gene therapy · 1999Article
- Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling.The Histochemical journal · 1996Review
- CD44/chondroitin sulfate proteoglycan and alpha 2 beta 1 integrin mediate human melanoma cell migration on type IV collagen and invasion of basement membranes.Molecular biology of the cell · 1996Article
- CD44: physiological expression of distinct isoforms as evidence for organ-specific metastasis formation.Journal of molecular medicine (Berlin, Germany) · 1995Review
- Intermediate filament typing of the human embryonic and fetal notochord.Cell and tissue research · 1995Article
- Distribution and quantification of alpha 1-integrin subunit in rat organs.The Histochemical journal · 1995Article
- Differential expression of beta 1, beta 3 and beta 4 integrins in sarcomas of the small, round, blue cell category.Virchows Archiv : an international journal of pathology · 1995Article
- Extracellular matrix in invasion and metastasis of oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrins encompass a family of cell-surface molecules which play a crucial role in cell-cell and cell-extracellular matrix interaction. Of these heterodimeric transmembrane glycoproteins (consisting of an alpha and beta chain) as yet at least 20 different types have been described, all with a different pattern of reactivity with extracellular matrix components. In this review the cell and tissue distribution of the integrins is discussed, with special emphasis on immunohistochemical localization of the beta 1 integrins and the alpha 6 beta 4 integrin. The beta 1 integrins comprise a subfamily in which eight alpha chains combine with one beta (the beta 1) chain. The alpha 2 beta 1, alpha 3 beta 1 and alpha 6 beta 1 and the alpha 6 beta 4 integrins are expressed on a wide variety of epithelia on the basolateral surface or exclusively on the basal surface facing the basement membrane (e.g. alpha 6 beta 1 and alpha 6 beta 4). Leucocyte integrins, which share a common beta 2 chain, occur almost exclusively on white blood cells and their precursors. The vitronectin receptors, which share a common alpha v chain, occur in a wide variety of cell types. Integrins play a major role in the interaction of the cell with the extracellular matrix in order to create and maintain tissue architecture. It has become clear, however, that through integrin-ligand interaction cell function is also modulated. Furthermore, in pathological conditions integrins play a role of some significance. Integrins mediate leucocyte traffic in developing inflammatory processes and function in neoplastic growth when it comes to invasion and metastasis.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.