ArticleInfection and immunity1993
Microtubule inhibitors block Cryptosporidium parvum infection of a human enterocyte cell line.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells.Infection and immunity · 2006Article
- Host cell tropism underlies species restriction of human and bovine Cryptosporidium parvum genotypes.Infection and immunity · 2004Article
- In vitro cultivation of cryptosporidium species.Clinical microbiology reviews · 2002Review
- Dicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlations.Antimicrobial agents and chemotherapy · 2001Article
- The effect of microfilament inhibitor on the Cryptosporidium infection in vitro.The Korean journal of parasitology · 2000Article
- Mechanisms of internalization of Staphylococcus aureus by cultured human osteoblasts.Infection and immunity · 1999Article
- Synthesis and evaluation of dinitroanilines for treatment of cryptosporidiosis.Antimicrobial agents and chemotherapy · 1998Article
- Effects of select medium supplements on in vitro development of Cryptosporidium parvum in HCT-8 cells.Journal of clinical microbiology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
No effective therapy exists for Cryptosporidium parvum, a coccidial protozoan parasite that causes severe diarrhea in patients with AIDS. The role of microtubules in parasite invasion of host cells was investigated by incubating 10(7) oocysts with a HT 29.74 cell line for 24 h in the presence of microtubule-disrupting drugs. The number of parasites per 1,000 cells was reduced by 77% (P < 0.001, n = 4) from 182 +/- 3 in untreated cells to 42 +/- 4 in cells treated with 10(-4) M colchicine. Inhibition of C. parvum infection was concentration dependent. Similar results were seen with a second microtubular depolymerization agent, vinblastine. These data suggest that microtubules are important in host cell invasion by C. parvum and may represent targets for development of new therapeutic drugs for treatment of cryptosporidiosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.