ArticleInfection and immunity1993
Phase variation of slime production in Staphylococcus aureus: implications in colonization and virulence.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 141 citations in OpenAlex.
- Study on molecular characteristics of Staphylococcus from yak milk-Xizang.BMC microbiology · 2025Article
- Preparation and characterization of Meta-bromo-thiolactone calcium alginate nanoparticles.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Phenotypic PIA-Dependent Biofilm Production by Clinical Non-TypeableAnimals : an open access journal from MDPI · 2021Article
- Staphylococcal Infections: Host and Pathogenic Factors.Microorganisms · 2021Article
- Chitosan-Coated Surgical Sutures Prevent Adherence and Biofilms of Mixed Microbial Communities.Current microbiology · 2021Article
- No Change, No Life? What We Know about Phase Variation inMicroorganisms · 2021Review
- Biofilm Research in Bovine Mastitis.Frontiers in veterinary science · 2021Review
- Article
- Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids.Scientific reports · 2020Article
- Revisiting Bap Multidomain Protein: More Than Sticking Bacteria Together.Frontiers in microbiology · 2020Review
- Epidemiological investigation of subclinical bovine mastitis in Algeria and molecular characterization of biofilm-forming Staphylococcus aureus.Tropical animal health and production · 2020Article
- Biofilm-Forming Potential of Staphylococcus aureus Isolated from Clinical Mastitis Cases in New Zealand.Veterinary sciences · 2018Article
- Article
- Phenotypic and genotypic characterization of canine pyoderma isolates of Staphylococcus pseudintermedius for biofilm formation.The Journal of veterinary medical science · 2015Article
- An association between milk and slime increases biofilm production by bovine Staphylococcus aureus.BMC veterinary research · 2015Article
- Comparison of methods for the detection of biofilm formation by Staphylococcus aureus isolated from bovine subclinical mastitis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
- Investigation of biofilm forming ability in Staphylococci causing bovine mastitis using phenotypic and genotypic assays.TheScientificWorldJournal · 2013Article
- A communal bacterial adhesin anchors biofilm and bystander cells to surfaces.PLoS pathogens · 2011Article
- An evaluation of casein hydrolyzate in combination with antibiotic for bacterial cure and subsequent increase in milk yield in dairy cows.BMC veterinary research · 2011Article
- Detection of intercellular adhesion genes and biofilm production in Staphylococcus aureus isolated from bovine subclinical mastitis.Veterinary research communications · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two methods commonly used for slime detection in coagulase-negative staphylococci (tube biofilm formation and colony morphology in Congo red agar) were used to study 144 ruminant mastitis Staphylococcus aureus strains. Slime production was detected in 21 strains. A majority of cells (85%) in slime-producing (SP) strains and a minority of cells (5%) in non-slime-producing (NSP) strains showed a condensed exopolysaccharide matrix (slime) surrounding the bacterial cell wall, as revealed by electron microscopy and immunofluorescence. In vivo slime production was also detected immunohistochemically after experimental infection of the mammary gland in sheep. Upon repeated subcultures in Congo red agar, NSP variants were obtained from four ovine and four bovine SP strains at a frequency ranging from 0.5 x 10(-4) to 10(-4). Because SP variants could not be obtained from NSP strains within this range or at a higher frequency, they were obtained by the tube biofilm formation (requiring repeated subculturing of NSP strains in tryptic soy broth containing 2% glucose for subsequent recovery of colonies adherent to the walls of the culture tubes). In experimental challenge, the SP variant showed a significantly higher colonization capacity than did the NSP variant of the same strain used (P < 0.001). However, the NSP variant had a higher virulence than did the SP variant (P < 0.001). These results may help to explain the different roles of S. aureus slime production cell types (SP and NSP) coexisting in disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.