ArticleInfection and immunity1993
Proliferative and cytokine responses to a major surface glycoprotein of Pneumocystis carinii.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murina.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.Infection and immunity · 2009Article
- Characterization of major surface glycoprotein genes of human Pneumocystis carinii and high-level expression of a conserved region.Infection and immunity · 1998Article
- Expression, structure, and location of epitopes of the major surface glycoprotein of Pneumocystis carinii f. sp. carinii.Clinical and diagnostic laboratory immunology · 1998Article
- The major surface glycoprotein of Pneumocystis carinii induces release and gene expression of interleukin-8 and tumor necrosis factor alpha in monocytes.Infection and immunity · 1997Article
- The role of alveolar macrophages in Pneumocystis carinii degradation and clearance from the lung.The Journal of clinical investigation · 1997Article
- Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat.The Journal of clinical investigation · 1995Article
- Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages.The Journal of clinical investigation · 1995Article
- Pneumocystis carinii glycoprotein A binds macrophage mannose receptors.Infection and immunity · 1995Article
- Cellular responses to a 55-kilodalton recombinant Pneumocystis carinii antigen.Infection and immunity · 1994Article
- Characterization of multiple unique cDNAs encoding the major surface glycoprotein of rat-derived Pneumocystis carinii.Parasitology research · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Naturally derived T-cell responses by rats to a 120-kDa major surface glycoprotein (MSG) of rat-derived Pneumocystis carinii were analyzed in vitro. Specific cytokines elicited by the T-cell response to the MSG were also identified. MSG was purified from rat-derived P. carinii by three different techniques: lectin affinity chromatography, sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by electroelution, and size-exclusion high-performance liquid chromatography. The cell-mediated immunity of spleen cells isolated from Lewis rats with and without natural exposure to P. carinii to the purified MSG was studied. Exposure to P. carinii was monitored by the presence or absence of serum antibodies to P. carinii antigens by Western blotting (immunoblotting). A T-cell proliferative response to the MSG was identified only with spleen cells isolated from rats exposed to P. carinii and peaked at 4 days. Flow cytometric analysis revealed that the percentage of CD4 cells was significantly increased during the proliferative response to MSG. MSG also elicited secretion of tumor necrosis factor alpha, interleukin-1, and interleukin-2, with peak activity of these cytokines occurring after 12, 24, and 48 h, respectively, of culture. These findings suggest that MSG is important in host T-cell recognition of and immune response to P. carinii by recruitment of inflammatory cells and cytokine production.
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