ArticleInfection and immunity1993
Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 192 citations in OpenAlex.
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- Overview of procalcitonin in pregnancy and in pre-eclampsia.Clinical and experimental immunology · 2019Review
- Efficacy of Intranasal Administration of the Recombinant Endolysin SAL200 in a Lethal Murine Staphylococcus aureus Pneumonia Model.Antimicrobial agents and chemotherapy · 2019Article
- Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus.Applied and environmental microbiology · 2016Article
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- Neutrophil-Mediated Phagocytosis of Staphylococcus aureus.Frontiers in immunology · 2014Review
- Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: host-microbe interactions in intraocular infection.Progress in retinal and eye research · 2012Review
- Host-bacterial symbiosis in health and disease.Advances in immunology · 2010Review
- Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.Nature medicine · 2009Article
- Modulation of muramyl dipeptide stimulation of cytokine production by blood components.Clinical and experimental immunology · 2009Article
- Mitogenic effect contributes to increased virulence of Streptococcus suis sequence type 7 to cause streptococcal toxic shock-like syndrome.Clinical and experimental immunology · 2008Article
- Pathogenesis of methicillin-resistant Staphylococcus aureus infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008Review
- Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications.Clinical and experimental immunology · 2007Article
- Beta-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes.Annals of clinical microbiology and antimicrobials · 2006Article
- Recognition of Staphylococcus aureus by the innate immune system.Clinical microbiology reviews · 2005Review
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of cytokines in gram-positive infections is still relatively poorly defined. The purpose of this study was to establish whether or not intact staphylococci and purified peptidoglycans and peptidoglycan components derived from staphylococci are capable of stimulating the release of tumor necrosis factor (TNF) by human monocytes. We show here that intact staphylococci and purified peptidoglycans, isolated from three Staphylococcus epidermidis and three S. aureus strains, were indeed able to induce secretion of TNF by human monocytes in a concentration-dependent fashion. TNF release was detected by both enzyme immunoassay and the L929 fibroblast bioassay. In the enzyme immunoassay, a minimal concentration of peptidoglycan of 1 micrograms/ml was required to detect TNF release by monocytes, whereas in the bioassay a peptidoglycan concentration of 10 micrograms/ml was needed to detect a similar amount of TNF release. Peptidoglycan components such as the stem peptide, tetra- and pentaglycine, and muramyl dipeptide were unable to induce TNF release from human monocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.