ArticleGut1993
Colonic dysfunction in acute diarrhoea: the role of luminal short chain fatty acids.
Article in Gut, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 87 citations in OpenAlex.
- Trial
- Partially hydrolysed guar gum supplemented comminuted chicken diet in persistent diarrhoea: a randomised controlled trial.Archives of disease in childhood · 2005Trial
- A metagenomic approach to unveil the association between fecal gut microbiota and short-chain fatty acids in diarrhea caused by diarrheagenicMicrobial cell (Graz, Austria) · 2024Article
- Molecular Targets of Valeric Acid: A Bioactive Natural Product for Endocrine, Metabolic, and Immunological Disorders.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Article
- MAFLD and Celiac Disease in Children.International journal of molecular sciences · 2023Review
- Influence of the Microbiota-Gut-Brain Axis on Cognition in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Review
- Observational
- Evaluation and comparison of short chain fatty acids composition in gut diseases.World journal of gastroenterology · 2019Observational
- Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine.Microbiome · 2019Article
- Chemoprevention in gastrointestinal physiology and disease. Natural products and microbiome.American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- Supra-organismal interactions in the human intestine.Frontiers in cellular and infection microbiology · 2014Review
- Lactobacillus GG and tributyrin supplementation reduce antibiotic-induced intestinal injury.JPEN. Journal of parenteral and enteral nutrition · 2013Article
- Current status and future promise of the human microbiome.Pediatric gastroenterology, hepatology & nutrition · 2013Review
- Treatment of infectious diarrhea in children.Paediatric drugs · 2003Review
- Towards a better oral rehydration fluid.Indian journal of pediatrics · 2001Review
- Stimulation of sodium chloride absorption from secreting rat colon by short-chain fatty acids.Digestive diseases and sciences · 1999Article
- Short-chain fatty acids inhibit fluid and electrolyte loss induced by cholera toxin in proximal colon of rabbit in vivo.Digestive diseases and sciences · 1999Article
- Quantitative and ultrastructural analysis of rectal mucosal mast cells in acute infectious diarrhea.Digestive diseases and sciences · 1998Article
- Influence of intestinal inflammation (IBD) and small and large bowel length on fecal short-chain fatty acids and lactate.Digestive diseases and sciences · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Faecal concentrations and output of short chain fatty acids (SCFA) were assessed on successive days by gas-liquid chromatography in 24 patients with acute watery diarrhoea. Absorption of water and sodium from the rectum was also measured by a dialysis technique in 17 of these patients and in nine normal subjects in the presence and absence of luminal SCFA. Faecal SCFA concentrations were low on the first day of diarrhoea (mean (SEM) 9.9 (5.8) mmol/kg) and increased to 94.8 (16.4) mmol/kg by the fifth day. Faecal output of SCFA corresponded to these figures. Net water absorption, in the absence of luminal SCFA, was stopped in patients with acute diarrhoea (-59 (81) nl/cm2/min) compared with healthy controls (+322 (63) nl/cm2/min) (p < 0.01). Luminal SCFA restored net water absorption to +184 (67) nl/cm2/min in patients with acute diarrhoea (p < 0.01). Net absorption of sodium decreased in patients with acute diarrhoea in the absence of luminal SCFA, but returned to normal with luminal SCFA. Net secretion of potassium increased in acute diarrhoea, and did not change in the presence of SCFA. Defective absorption from the rectum in acute diarrhoea is reversed by luminal SCFA. The reduction of luminal SCFA in acute diarrhoea treated conventionally may be a factor contributing to colonic dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.