ArticleDiabetologia1993
Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats.
Article in Diabetologia, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Role of Reactive Oxygen Species in Glucose Metabolism Disorder in Diabetic Pancreatic β-Cells.Biomolecules · 2022Review
- Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus.Healthcare (Basel, Switzerland) · 2015Review
- Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.The Biochemical journal · 2015Article
- Article
- Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.The Journal of biological chemistry · 2011Article
- Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.Archives of biochemistry and biophysics · 2010Article
- Article
- Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes.Diabetologia · 2009Article
- Hypoglycaemia induces decreased islet blood perfusion mediated by the central nervous system in normal and Type 2 diabetic GK rats.Diabetologia · 2003Article
- Article
- Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets.Endocrine · 1998Review
- Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.Diabetologia · 1995Article
- Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Reduced sensitivity of dihydroxyacetone on ATP-sensitive K+ channels of pancreatic beta cells in GK rats.Diabetologia · 1994Article
- Impaired skeletal muscle glycogen synthase activation by insulin in the Goto-Kakizaki (G/K) rat.Diabetologia · 1994Article
- The role of islet secretory function in the development of diabetes in the GK Wistar rat.Diabetologia · 1994Article
- The beta cell in NIDDM: giving light to the blind.Diabetologia · 1994Review
- Impaired FAD-glycerophosphate dehydrogenase activity in islet and liver homogenates of fa/fa rats.Molecular and cellular biochemistry · 1994Article
- Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients.Diabetologia · 1994Article
- Metabolism of endogenous nutrients in islets of Goto-Kakizaki (GK) rats.The Biochemical journal · 1993Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
In pancreatic islet extracts of rats with hereditary non-insulin-dependent diabetes mellitus (GK rats), the activity of the mitochondrial FAD-linked glycerophosphate dehydrogenase, as measured by either a radioisotopic or colorimetric procedure, only represented 30 to 40% of that found in control rats. This decrease in enzymic activity was not attributable to any sizeable change in either islet DNA content or the relative contribution of insulin-producing beta cells to total islet mass. It contrasted with a normal activity of other mitochondrial dehydrogenases and hexokinase isoenzymes. It coincided, however, with an increased activity of glutamate-pyruvate transaminase, as already observed in adult rats injected with streptozotocin during the neonatal period. The decreased activity of islet FAD-linked glycerophosphate dehydrogenase also contrasted with an increased activity of the same enzyme in the liver of GK, as compared to control rats. In the light of these findings and recent metabolic data collected in intact islets of GK rats, it is proposed that a deficiency of beta-cell FAD-linked glycerophosphate dehydrogenase, the key enzyme of the glycerol phosphate shuttle, may represent a cause of inherited non-insulin-dependent diabetes.
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