ArticleThe EMBO journal1993
Alternating d(GA)n DNA sequences form antiparallel stranded homoduplexes stabilized by the formation of G.A base pairs.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures.Nucleic acids research · 2026Article
- G-QINDER Tool: Bioinformatically Predicted Formation of Different Four-Stranded DNA Motifs from (GT)International journal of molecular sciences · 2023Article
- Trinucleotide repeat DNA alters structure to minimize the thermodynamic impact of 8-oxo-7,8-dihydroguanine.Biochemistry · 2012Article
- Premutation huntingtin allele adopts a non-B conformation and contains a hot spot for DNA damage.Biochemical and biophysical research communications · 2011Article
- Structure of even/odd trinucleotide repeat sequences modulates persistence of non-B conformations and conversion to duplex.Biochemistry · 2011Article
- AGG interruptions in (CGG)(n) DNA repeat tracts modulate the structure and thermodynamics of non-B conformations in vitro.Biochemistry · 2010Article
- DNA homoduplexes containing no pyrimidine nucleotide.European biophysics journal : EBJ · 2003Article
- Conformational properties of DNA strands containing guanine-adenine and thymine-adenine repeats.Nucleic acids research · 1998Article
- Parallel-stranded linear homoduplexes of d(A+-G)n > 10 and d(A-G)n > 10 manifesting the contrasting ionic strength sensitivities of poly(A+.A+) and DNA.Nucleic acids research · 1997Article
- Through-bond correlation of adenine H2 and H8 protons in unlabeled DNA fragments by HMBC spectroscopy.Journal of biomolecular NMR · 1996Article
- Identification of two novel arginine binding DNAs.The EMBO journal · 1995Article
- Formation of a parallel-stranded DNA homoduplex by d(GGA) repeat oligonucleotides.Nucleic acids research · 1995Article
- Effect of competing self-structure on triplex formation with purine-rich oligodeoxynucleotides containing GA repeats.Nucleic acids research · 1995Article
- Parallel-stranded duplex DNA containing blocks of trans purine-purine and purine-pyrimidine base pairs.Nucleic acids research · 1994Article
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5 authors.
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Abstract
Alternating d(GA)n DNA sequences form antiparallel stranded homoduplexes which are stabilized by the formation of G.A pairs. Three base pairings are known to occur between adenine and guanine: AH+ (anti).G(syn), A(anti).G(anti) and A(syn).G(anti). Protonation of the adenine residues is not involved in the stabilization of this structure, since it is observed at any pH value from 8.3 to 4.5; at pH < or = 4.0 antiparallel stranded d(GA.GA) DNA is destabilized. The results reported in this paper strongly suggest that antiparallel stranded d(GA.GA) homoduplexes are stabilized by the formation of alternating A(anti).G(anti) and G(anti).A(syn) pairs. In this structure, all guanine residues are in the anti conformation with their N7 position freely accessible to DMS methylation. On the other hand, adenines in one strand adopt the anti conformation, with their N7 position also free for reaction, while those of the opposite strand are in the syn conformation, with their N7 position hydrogen bonded to the guanine N1 group of the opposite strand. A regular right-handed helix can be generated using alternating G(anti).A(syn) and A(anti).G(anti) pairs.
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