ArticleThe EMBO journal1993
Degradation of Mos by the N-terminal proline (Pro2)-dependent ubiquitin pathway on fertilization of Xenopus eggs: possible significance of natural selection for Pro2 in Mos.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 126 citations in OpenAlex.
- Spindle morphology changes between meiosis and mitosis driven by CK2 regulation of the Ran pathway.The Journal of cell biology · 2025Article
- Egg Overactivation-An Overlooked Phenomenon of Gamete Physiology.International journal of molecular sciences · 2025Review
- Contributions of UBE2C and UBE2S to meiotic progression of porcine oocytes.The Journal of reproduction and development · 2018Article
- Postovulatory cell death: why eggs die via apoptosis in biological species with external fertilization.The Journal of reproduction and development · 2018Review
- Vertebrate Reproduction.Cold Spring Harbor perspectives in biology · 2015Review
- Calcium signaling and meiotic exit at fertilization in Xenopus egg.International journal of molecular sciences · 2014Review
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- Kicked by Mos and tuned by MPF-the initiation of the MAPK cascade in Xenopus oocytes.HFSP journal · 2009Article
- Survey of O-GlcNAc level variations in Xenopus laevis from oogenesis to early development.Glycoconjugate journal · 2009Article
- The Xenopus cell cycle: an overview.Molecular biotechnology · 2008Review
- Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1.Oncogene · 2008Article
- Mechanistic studies of the mitotic activation of Mos.Molecular and cellular biology · 2006Article
- Identification of alpha-type subunits of the Xenopus 20S proteasome and analysis of their changes during the meiotic cell cycle.BMC biochemistry · 2004Article
- The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity.Molecular and cellular biology · 2003Article
- Dissection of c-MOS degron.The EMBO journal · 2002Article
- Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes.Molecular biology of the cell · 2001Article
- The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes.Molecular biology of the cell · 2001Article
- Two distinct mechanisms control the accumulation of cyclin B1 and Mos in Xenopus oocytes in response to progesterone.Molecular biology of the cell · 1999Article
- Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos.Oncogene · 1999Article
- Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association.Oncogene · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The c-mos proto-oncogene product (Mos), an essential component of the cytostatic factor responsible for meiotic arrest in vertebrate eggs, undergoes specific proteolysis soon after fertilization or activation of Xenopus eggs. To determine the degradation pathway of Mos on egg activation, various Mos mutants were expressed in Xenopus eggs and their degradation on egg activation was examined. Mos degradation absolutely required its penultimate proline (Pro2) residue and dephosphorylation of the adjacent serine (Ser3) residue. These degradation signals were essentially the same as those of Mos in meiosis I of Xenopus oocyte maturation, where Mos has been shown to be degraded by the 'second-codon rule'-based ubiquitin pathway. To test whether Mos degradation on egg activation is also mediated by the ubiquitin pathway, we attempted to identify and abrogate a specific ubiquitination site(s) in Mos. We show that the major ubiquitination site in Mos is a Lys34 residue and that replacement of this residue with a non-ubiquitinatable Arg residue markedly enhances the stability of Mos on egg activation. These results indicate that the degradation of Mos on egg activation or fertilization is mediated primarily by the N-terminal Pro2-dependent ubiquitin pathway, as in meiosis I of oocyte maturation. The N-terminal Pro2 residue of Mos appears to be naturally selected primarily for its degradation on fertilization, rather than that in meiosis I.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.