Trial reportCalcified tissue international1993
Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss.
Trial report in Calcified tissue international, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 105 citations in OpenAlex.
- Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.Journal of bone and mineral metabolism · 2014Trial
- Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Trial
- Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women.Journal of bone and mineral metabolism · 2008Trial
- Manipulated Spawning Along With an Extension of the Atlantic Salmon Broodfish Feeding Period Affect the Vitamin C, E, D, and K Status of Broodfish, Eggs, and First-Feeding Fry.Aquaculture nutrition · 2025Article
- Osteokines and the vasculature: a review of thePeerJ · 2019Article
- Vitamin K-dependent carboxylation of osteocalcin: friend or foe?Advances in nutrition (Bethesda, Md.) · 2012Review
- Vitamin K: the effect on health beyond coagulation - an overview.Food & nutrition research · 2012Article
- From space to Earth: advances in human physiology from 20 years of bed rest studies (1986-2006).European journal of applied physiology · 2007Review
- Ethnic differences in osteocalcin gamma-carboxylation, plasma phylloquinone (vitamin K1) and apolipoprotein E genotype.European journal of clinical nutrition · 2005Article
- Bone health. New role for vitamin K?Canadian family physician Medecin de famille canadien · 2004Review
- Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin.The Biochemical journal · 2002Article
- Vitamin K and metabolic bone disease.Journal of clinical pathology · 1998Article
- Vitamin supplementation therapy in the elderly.Drugs & aging · 1997Review
- Seasonal differences in biochemical parameters of bone remodelling.Journal of clinical pathology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to identify subjects in whom vitamin K has an effect on markers for calcium and bone metabolism and to detect hitherto-unnoticed correlations between vitamin K-induced changes in these markers. Participants in our studies were apparently healthy women, in whom we measured serum-immunoreactive osteocalcin (irOC) before and after adsorption to hydroxylapatite; total serum alkaline phosphatase (T-AP) and bone-specific alkaline phosphatase (B-AP); and fasting urinary calcium and creatinine. We describe a trial among 145 women who were treated with vitamin K (1 mg/day) for 2 weeks, and a prospective placebo-controlled trial among two groups each of 70 postmenopausal women with a treatment period of 3 months. It turned out that in elderly women vitamin K induced increased levels of serum irOC with a high affinity for hydroxylapatite (irOCbound), whereas that with low affinity (irOCfree) remained unaffected. In placebo-treated women the ratio irOCfree/irOCbound shifted from 0.38 to 0.65 around the 50th year of age. This shift was not found in vitamin K-treated women. After 3 months of treatment the vitamin K-induced changes in irOCbound were correlated with changes in B-AP, whereas irOCfree was correlated to urinary calcium excretion. In fast losers of urinary calcium vitamin K induced a 30% decrease of calcium excretion. The hypothesis is put forward that irOCbound may be a marker for bone formation, that serum irOCfree may be a marker for bone resorption, and that the serum irOCfree/irOCbound ratio may become a marker for skeletal remodeling.(ABSTRACT TRUNCATED AT 250 WORDS)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.