ArticleBritish journal of pharmacology1993
Caffeine-induced decreases in the inward rectifier potassium and the inward calcium currents in rat ventricular myocytes.
Article in British journal of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Caffeine-induced hypokalemia: a case report.BMC nephrology · 2021Article
- Regulation of CaCell calcium · 2019Article
- Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine.Journal of molecular and cellular cardiology · 2009Article
- Effects of caffeine on potassium currents in isolated rat ventricular myocytes.Pflugers Archiv : European journal of physiology · 2003Article
- Investigation of the role of intracellular Ca(2+) stores in generation of the muscarinic agonist-induced slow afterdepolarization (sADP) in guinea-pig olfactory cortical neurones in vitro.British journal of pharmacology · 2000Article
- Effects of caffeine and 3-isobutyl-1-methylxanthine on voltage-activated potassium currents in vertebrate neurones and secretory cells.British journal of pharmacology · 1996Article
- Caffeine-induced oscillations of cytosolic Ca2+ in GH3 pituitary cells are not due to Ca2+ release from intracellular stores but to enhanced Ca2+ influx through voltage-gated Ca2+ channels.Pflugers Archiv : European journal of physiology · 1996Article
- Veratridine-induced oscillations of cytosolic calcium and membrane potential in bovine chromaffin cells.The Journal of physiology · 1995Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The effects of high (20 mM) concentrations of caffeine were studied on the transmembrane voltage and currents in rat single ventricular myocytes by the whole cell configuration of the patch clamp technique. Rapid application of caffeine released Ca2+ from the sarcoplasmic reticulum and induced a Ni(2+)-sensitive transient inward current with concomitant change of the transmembrane voltage from -72.6 +/- 0.4 to -68.0 +/- 0.6 mV (n = 4). Maintained application of caffeine lengthened the action potential duration (APD90) from 66.7 +/- 16.9 to 135.1 +/- 34.1 ms (n = 4) and depressed the amplitude of both the inward rectifier potassium and the inward calcium currents. It is concluded that these effects of caffeine should be recognized when it is used as a tool to study electromechanical coupling.
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