Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA1993
Acute biochemical variations induced by four different calcium salts in healthy male volunteers.
Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Postprandial effects of calcium phosphate supplementation on plasma concentration-double-blind, placebo-controlled cross-over human study.Nutrition journal · 2013Trial
- Effects of two marine dietary supplements with high calcium content on calcium metabolism and biochemical marker of bone resorption.European journal of clinical nutrition · 2008Trial
- Rapid suppression of bone resorption and parathyroid hormone secretion by acute oral administration of calcium in healthy adult men.Journal of endocrinological investigation · 2003Trial
- Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption.European journal of clinical nutrition · 2003Trial
- Acute changes in serum calcium and parathyroid hormone circulating levels induced by the oral intake of five currently available calcium salts in healthy male volunteers.Clinical rheumatology · 1997Trial
- Intestinal calcium absorption from different calcium preparations: influence of anion and solubility.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1996Trial
- Comparative Evaluation of Bioavailability, Efficacy and Safety of MICROCORE NESCIndian journal of orthopaedics · 2024Article
- What is hypercalcemia? The importance of fasting samples.Cardiorenal medicine · 2013Article
- Calcium intake and prostate cancer among African Americans: effect modification by vitamin D receptor calcium absorption genotype.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Calcium and vitamin D supplementation during androgen deprivation therapy for prostate cancer: a critical review.The oncologist · 2012Review
- Calcium citrate and vitamin D in the treatment of osteoporosis.Clinical drug investigation · 2011Review
- Effect of acute oral calcium load on serum PTH and bone resorption in young healthy subjects: an overnight study.European journal of clinical nutrition · 2004Article
- Comparative study of the intestinal absorption of three salts of calcium in young and elderly women.Journal of endocrinological investigation · 1998Article
- Acute effects induced by a calcium-rich mineral water on calcium metabolism and on parathyroid function.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1997Article
- Effect of an oral calcium load on urinary markers of collagen breakdown.Journal of endocrinological investigation · 1996Article
- Role of calcium and vitamin D in the prevention and the treatment of postmenopausal osteoporosis: an overview.Clinical rheumatology · 1995Review
- Acute biochemical variations induced by two different calcium salts in healthy perimenopausal women.Calcified tissue international · 1995Article
- Comparison of the biochemical and hormonal acute effects of calcium salts.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1995Article
- A Randomized Open-Label Clinical Study Comparing the Efficacy, Safety, and Bioavailability of Calcium Lysinate with Calcium Carbonate and Calcium Citrate Malate in Osteopenia Patients.Journal of orthopaedic case reportsArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium (Ca) supplements have positive effects in growing children, reduce bone loss in late-postmenopausal women with a low calcium diet and, in association with vitamin D3 supplements, may reduce non-vertebral fracture rates in elderly women. However, for many formulated pharmaceutical products their relative beneficial effects have not been conclusively established. We have compared the acute (6 h) metabolic responses following oral administration of two preparations of calcium gluconolactate and carbonate (CG and CG'), tricalcium phosphate (TCP) and calcium citrate (CC), given on separate occasions in each of 10 healthy young male volunteers. The subjects fasted overnight for 12 h and continued to fast during the experimental procedure. A 1000 mg dose of each Ca salt was ingested at weekly intervals. Blood was drawn after 30, 60, 90, 120, 180, 240, 300 and 360 min for measurement of serum Ca, phosphorus (P), parathyroid hormone (PTH) and whole plasma calcitonin (iCT). All Ca supplements induced significant (+6.4% to +8.1%; p < 0.01) increases in Ca and significant suppression of PTH (-37.4% to -57.4%; p < 0.01). Comparison of response curves revealed significantly (p < 0.01) more marked Ca increase and PTH suppression with CC than with the other three Ca salts. CG' and CC induced marginal decreases in serum P and the overall curve of P variations was different for TCP compared with CG, CG' and CC. No significant variation of iCT was recorded during the test.(ABSTRACT TRUNCATED AT 250 WORDS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.