ArticleInternational journal of legal medicine1993
Immunohistochemical localization of collagen types I and VI in human skin wounds.
Article in International journal of legal medicine, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Forensic Impact of the Omics Science Involved in the Wound: A Systematic Review.Frontiers in medicine · 2021Pooled it
- Topical hyaluronic acid serum, oral vitamin C, and their combined regimen modulate collagen-related repair indices in a sutured primary-intention rat incisional wound model.Journal of molecular histology · 2026Article
- Promotion of DFU Wound Healing via BRG1-COL16A1 Axis in Fibroblasts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dating Skin Lesions of Forensic Interest by Immunohistochemistry and Immunofluorescence Techniques: A Scoping Literature Review.Diagnostics (Basel, Switzerland) · 2024Article
- Minor collagens of the skin with not so minor functions.Journal of anatomy · 2019Review
- Temporal expression of chitinase-like 3 in wounded murine skin.International journal of legal medicine · 2017Article
- Solving the Measurement Problem and then Steppin' Out over the Line Riding the Rarest Italian: Crossing the Streams to Retrieve Stable Bioactivity in Majorana Bound States of Dialy zed Human Platelet Lysates.The open neurology journal · 2015Article
- The role of histopathology in forensic practice: an overview.Forensic science, medicine, and pathology · 2014Review
- A time-course analysis of mRNA expression during injury healing in human dermal injuries.International journal of legal medicine · 2014Article
- The myofibroblast matrix: implications for tissue repair and fibrosis.The Journal of pathology · 2013Review
- Detection of fibrocytes in human skin wounds and its application for wound age determination.International journal of legal medicine · 2009Article
- Time-dependent appearance of intrathrombus neutrophils and macrophages in a stasis-induced deep vein thrombosis model and its application to thrombus age determination.International journal of legal medicine · 2009Article
- Expression of oxygen-regulated protein 150 (ORP150) in skin wound healing and its application for wound age determination.International journal of legal medicine · 2008Article
- Forensic application of VEGF expression to skin wound age determination.International journal of legal medicine · 2004Article
- Immunohistochemical detection of chemokines in human skin wounds and its application to wound age determination.International journal of legal medicine · 2002Article
- Immunohistochemical study on the expression of c-Fos and c-Jun in human skin wounds.The Histochemical journal · 2000Article
- The dynamics of inflammatory cytokines in the healing process of mouse skin wound: a preliminary study for possible wound age determination.International journal of legal medicine · 1996Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 74 human skin wounds were investigated and collagen types I and VI were localized in the wound area by immunohistochemistry. Collagen type I appeared in the form of ramifying string-like structures after approximately 5-6 days, but positive reactions in the form of a spot-like staining around isolated fibroblasts also occurred in a skin wound aged 4 days. Collagen VI was detectable after a post-infliction interval of at least 3 days showing a strongly positive reacting network associated with fibroblasts in the wound area. Both collagens appeared almost constantly after a wound age of 6-7 days and could also be found in wounds aged a few months. Therefore, although a positive reaction for collagen type I in the form of string-like and ramifying structures around wound fibroblasts indicates a wound age of at least 5-6 days, a spot-like positive staining for collagen type I cannot exclude a wound age of at least 4 days. A positive staining for collagen type VI represents a post-infliction time of 3 days or more. The almost constant appearance of these collagen types suggests that negative results in a sufficient number of specimens indicate a wound age of less than 6-7 days, but cannot completely exclude longer post-infliction intervals. Since collagen type I and VI are also found in the granulation/scar tissue of lesions with advanced wound age, the immunohistochemical analysis of these proteins provides no further information for an age determination of older skin wounds.
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