ArticleBritish journal of cancer1993
Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
Article in British journal of cancer, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
- Postoperative Prognostic Predictors of Bile Duct Cancers: Clinical Analysis and Immunoassays of Tissue Microarrays.Gut and liver · 2023Article
- Young age increases the risk of lymph node positivity in papillary thyroid cancer patients: a SEER data-based study.Cancer management and research · 2018Article
- Expression of the estrogen receptor α, progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues.Oncology letters · 2015Article
- Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma.Medical oncology (Northwood, London, England) · 2012Article
- Anaplastic thyroid carcinoma.Frontiers in endocrinology · 2012Article
- In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- Anaplastic thyroid carcinoma: A comprehensive review of current and future therapeutic options.World journal of clinical oncology · 2011Article
- EGF and TGF-β1 Effects on Thyroid Function.Journal of thyroid research · 2011Article
- Multi-targeted approach in the treatment of thyroid cancer.Minerva chirurgica · 2010Review
- Article
- Targeting the EGF/VEGF-R system by tyrosine-kinase inhibitors--a novel antiproliferative/antiangiogenic strategy in thyroid cancer.Langenbeck's archives of surgery · 2006Article
- Functional thyrotropin receptor attenuates malignant phenotype of follicular thyroid cancer cells.Endocrine · 2006Article
- Significance of vascular endothelial growth factor and epidermal growth factor in development of papillary thyroid cancer.Langenbeck's archives of surgery · 2005Article
- Her2/neu overexpression in differentiated thyroid carcinomas predicts metastatic disease.Virchows Archiv : an international journal of pathology · 2003Article
- The role of epidermal growth factor receptor in head and neck squamous cell carcinoma.Current oncology reports · 2003Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.