ArticleThe Journal of cell biology1993
Three-dimensional solution structure of Acanthamoeba profilin-I.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 81 citations in OpenAlex.
- Profilin choreographs actin and microtubules in cells and cancer.International review of cell and molecular biology · 2020Article
- Article
- Profilin binding to poly-L-proline and actin monomers along with ability to catalyze actin nucleotide exchange is required for viability of fission yeast.Molecular biology of the cell · 2001Article
- Protein phi and psi dihedral restraints determined from multidimensional hypersurface correlations of backbone chemical shifts and their use in the determination of protein tertiary structures.Journal of biomolecular NMR · 1997Article
- Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function.The EMBO journal · 1996Article
- The Arabidopsis profilin gene family. Evidence for an ancient split between constitutive and pollen-specific profilin genes.Plant physiology · 1996Article
- Purification, characterization, and cDNA cloning of profilin from Phaseolus vulgaris.Plant physiology · 1995Article
- Refined solution structure of human profilin I.Protein science : a publication of the Protein Society · 1995Article
- X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- 1H, 15N, 13C and 13CO resonance assignments and secondary structure of villin 14T, a domain conserved among actin-severing proteins.Journal of biomolecular NMR · 1994Article
- The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis.The Journal of cell biology · 1994Article
- Mutational analysis of yeast profilin.Molecular and cellular biology · 1993Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have determined a medium resolution three-dimensional solution structure of Acanthamoeba profilin-I by multidimensional nuclear magnetic resonance spectroscopy. This 13-kD actin binding protein consists of a five stranded antiparallel beta sheet flanked by NH2- and COOH-terminal helices on one face and by a third helix and a two stranded beta sheet on the other face. Data from actin-profilin cross-linking experiments and the localization of conserved residues between profilins in different phyla indicate that actin binding occurs on the molecular face occupied by the terminal helices. The other face of the molecule contains the residues that differ between Acanthamoeba profilins-I and II and may be important in determining the difference in polyphosphoinositide binding between these isoforms. This suggests that lipids and actin bind to different faces of the molecule.
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