ArticleJournal of molecular evolution1993
Rates of amino acid change in the envelope protein correlate with pathogenicity of primate lentiviruses.
Article in Journal of molecular evolution, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission.Retrovirology · 2015Article
- Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3.Journal of virology · 2007Article
- The key role for local base order in the generation of multiple forms of China HIV-1 B'/C intersubtype recombinants.BMC evolutionary biology · 2005Article
- Epidemiology, genetic diversity, and evolution of endemic feline immunodeficiency virus in a population of wild cougars.Journal of virology · 2003Article
- Compartmentalization of surface envelope glycoprotein of human immunodeficiency virus type 1 during acute and chronic infection.Journal of virology · 2002Article
- Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease.Journal of virology · 2001Article
- Evolution and biological characterization of human immunodeficiency virus type 1 subtype E gp120 V3 sequences following horizontal and vertical virus transmission in a single family.Journal of virology · 1999Article
- Shortening of the symptom-free period in rhesus macaques is associated with decreasing nonsynonymous variation in the env variable regions of simian immunodeficiency virus SIVsm during passage.Journal of virology · 1998Article
- Structured-tree topology and adaptive evolution of the simian immunodeficiency virus SIVsm envelope during serial passage in rhesus macaques according to likelihood mapping and quartet puzzling.Journal of virology · 1998Article
- Extensive diversification of human immunodeficiency virus type 1 subtype B strains during dual infection of a chimpanzee that progressed to AIDS.Journal of virology · 1998Article
- Tempo and mode of nucleotide substitutions in gag and env gene fragments in human immunodeficiency virus type 1 populations with a known transmission history.Journal of virology · 1997Article
- Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades.Journal of virology · 1997Article
- Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo.Journal of virology · 1997Article
- Positive selection and rates of evolution in immunodeficiency viruses from humans and chimpanzees.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Stem-loop potential in MHC genes: a new way of evaluating positive Darwinian selection?Immunogenetics · 1996Article
- Convergent evolution within the V3 loop domain of human immunodeficiency virus type 1 in association with disease progression.Journal of virology · 1995Article
- Substitution rates in hepatitis delta virus.Journal of molecular evolution · 1995Review
- Reciprocal relationship between stem-loop potential and substitution density in retroviral quasispecies under positive Darwinian selection.Journal of molecular evolution · 1995Article
- Variability of human immunodeficiency virus type 1 group O strains isolated from Cameroonian patients living in France.Journal of virology · 1995Article
- Mutational trends in V3 loop protein sequences observed in different genetic lineages of human immunodeficiency virus type 1.Journal of virology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A spectrum of pathogenicity has been observed for primate lentiviruses in their natural hosts. For example, human immunodeficiency virus type 1 (HIV-1) is a potent etiologic agent for AIDS in man, whereas there is no evidence to date which indicates that simian immunodeficiency virus from African green monkeys (SIVAGM) causes immunodeficiency in AGM. We measured the relative rates of amino acid change, as the ratio of the number of nonsynonymous to synonymous (silent) nucleotide substitutions, for six primate lentiviruses evolving in their respective hosts. These rates for the external envelope glycoprotein (gp120) and gag coding sequences are 2-3 times higher for pathogenic HIV-1 and SIVmac (macaque) than for minimally pathogenic SIVAGM and SIVsmm (sooty mangabey), and intermediate for HIV-2. We speculate that the increased rates of nonsynonymous changes in gp120 and gag coding sequences are due to viral escape from immune surveillance and are indicative of higher immunogenicity of these proteins in their hosts. Based on these results and available experimental data, we conclude that there is a positive correlation between lentiviral pathogenicity and immunogenicity of the Env and Gag proteins in a given host. This hypothesis is consistent with recent data suggesting that immune system activation or autoimmunity induced by viral antigens may be important in the pathogenesis of AIDS.
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