ArticleThe Biochemical journal1993
Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes.
Article in The Biochemical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Expression variations of two retinoid signaling pathway receptors in the rotifer Brachionus calyciflorus exposed to three endocrine disruptors.Ecotoxicology (London, England) · 2021Article
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- A novel bidirectional interaction between endothelin-3 and retinoic acid in rat enteric nervous system precursors.PloS one · 2013Article
- Lipophilic micronutrients and adipose tissue biology.Nutrients · 2012Review
- Retinoic acid synthesis and functions in early embryonic development.Cell & bioscience · 2012Article
- Vitamin A metabolism: an update.Nutrients · 2011Review
- RARgamma and TRbeta expressions are decreased in PBMC and SWAT of obese subjects in weight gain.Journal of physiology and biochemistry · 2010Article
- Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches.Developmental biology · 2009Article
- How degrading: Cyp26s in hindbrain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Review
- Article
- The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3.EMBO reports · 2005Article
- Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins.The Biochemical journal · 2004Article
- Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription.Molecular and cellular biology · 1997Article
- Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARgamma.Molecular and cellular biology · 1996Article
- The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat.Molecular and cellular biology · 1995Article
- Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinoids, especially all-trans retinoic acid (RA), have been shown to inhibit the differentiation of preadipose cells. In the present study, the expression of retinoic acid receptors (RAR alpha, beta and gamma) and retinoid X receptors (RXR alpha, beta and gamma) was examined by Northern blot analysis in rat adipose tissue and mouse 3T3-L1 adipose cells. The adipose tissue and/or 3T3-L1 cells expressed mRNAs for a number of nuclear retinoid receptors, including RAR alpha, beta and gamma, and RXR alpha, beta and gamma. RAR alpha, RAR gamma, RXR alpha and RXR beta mRNAs were abundant in adipose tissue and 3T3-L1 cells. RXR gamma mRNA was detected in adipose tissue but not in 3T3-L1 cells. Treatment of 3T3-L1 cells with 1 microM RA led to a 4-5-fold increase in the RAR gamma mRNA level, but only a trace amount of RAR beta mRNA was detected. RAR gamma mRNA expression was rapidly (within 2 h) induced by physiological concentrations of RA in a dose-dependent manner. The response of RAR gamma mRNA expression to RA was reversible; rapid disappearance of RAR gamma mRNA occurred on RA removal. In addition, the induction of RAR gamma expression did not require de novo protein synthesis, but was completely abolished by an inhibitor of RNA synthesis. Using RAR gamma 1 and gamma 2 isoform-specific probes, the patterns of RAR gamma 1 and gamma 2 mRNA expression in 3T3-L1 cells in the presence and absence of RA were examined. RAR gamma 1 mRNA was detected in 3T3-L1 cells but was not affected by RA treatment; however, RAR gamma 2 mRNA was strongly induced by RA.
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