ArticlePflugers Archiv : European journal of physiology1993
Intracellular ATP and GTP are both required to preserve modulation of N-type calcium channel current by norepinephrine.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- KJournal of neurophysiology · 2021Article
- NaJournal of neurophysiology · 2018Article
- Ceramide modulates HERG potassium channel gating by translocation into lipid rafts.American journal of physiology. Cell physiology · 2010Article
- State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.American journal of physiology. Cell physiology · 2009Article
- ADP exerts a protective effect against rundown of the Ca2+ current in bovine chromaffin cells.Pflugers Archiv : European journal of physiology · 1995Article
- Concentration dependence of neurotransmitter effects on calcium current kinetics in frog sympathetic neurones.The Journal of physiology · 1994Article
- Phosphorylation enhances inactivation of N-type calcium channel current in bullfrog sympathetic neurons.Pflugers Archiv : European journal of physiology · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Norepinephrine (NE) inhibits voltage-dependent calcium channels of sympathetic neurons. We investigated the role of intracellular nucleotides in this inhibition for clues to receptor-channel coupling mechanisms. Both ATP and GTP are required to preserve NE responsiveness during whole-cell dialysis. The response to NE was gradually lost in bullfrog sympathetic neurons dialyzed with GTP as the only nucleotide, ATP only, or no nucleotides. Replacing ATP with ATP[gamma-S] resulted in spontaneous modulation of calcium channel current, possibly because of production of GTP[gamma-S]. The nonhydrolyzable ATP analog p[NH]ppA could substitute for ATP to preserve NE responsiveness. The protein phosphatase inhibitors okadaic acid and calyculin-A did not affect NE inhibition of calcium channel current, or recovery from that inhibition. These results suggest protein phosphorylation is not involved in the inhibition of calcium channel current, but binding of ATP to some intracellular site is required for the coupling of adrenergic receptors to calcium channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.