ArticleJournal of clinical microbiology1993
Distribution of VP4 gene alleles in human rotaviruses by using probes to the hyperdivergent region of the VP4 gene.
Article in Journal of clinical microbiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Divergence of VP7 genes of G1 rotaviruses isolated from infants vaccinated with reassortant rhesus rotaviruses.Archives of virology · 1996Trial
- Diversity of rotavirus strains among children with acute diarrhea in China: 1998-2000 surveillance study.Journal of clinical microbiology · 2002Article
- Rotavirus strains bearing genotype G9 or P[9] recovered from Brazilian children with diarrhea from 1997 to 1999.Journal of clinical microbiology · 2001Article
- Isolation of a human rotavirus strain with a super-short RNA pattern and a new P2 subtype.Journal of clinical microbiology · 1999Article
- Comparison of enzyme immunoassay, PCR, and type-specific cDNA probe techniques for identification of group A rotavirus gene 4 types (P types).Journal of clinical microbiology · 1997Article
- Classification of rotavirus into G and P types with specimens from children with acute diarrhea in New Delhi, India.Journal of clinical microbiology · 1996Article
- Survey of equine rotaviruses shows conservation of one P genotype in background of two G genotypes.Archives of virology · 1996Article
- G3P2 rotaviruses causing diarrhoeal disease in neonates differ in VP4, VP7 and NSP4 sequence from G3P2 strains causing asymptomatic neonatal infection.Archives of virology · 1996Article
- Heterogeneity of VP4 neutralization epitopes among serotype P1A human rotavirus strains.Clinical and diagnostic laboratory immunology · 1995Article
- Geographic distribution of human rotavirus VP4 genotypes and VP7 serotypes in five South African regions.Journal of clinical microbiology · 1995Article
- Distribution of both rotavirus VP4 genotypes and VP7 serotypes among hospitalized and nonhospitalized Israeli children.Journal of clinical microbiology · 1995Article
- Serological and genomic characterisation of group A rotaviruses from lambs.Archives of virology · 1995Article
- Preferential selection of VP7 gene from a parent rotavirus strain (SA11) in sequential passages after mixed infection with SA11 and SA11-human rotavirus single-VP7 gene-substitution reassortants.Archives of virology · 1995Article
- Survey of rotavirus G and P types associated with human gastroenteritis in São Paulo, Brazil, from 1986 to 1992.Journal of clinical microbiology · 1994Article
- Characterization of rotavirus strains from newborns in New Delhi, India.Journal of clinical microbiology · 1994Article
- Survey on the distribution of the gene 4 alleles of human rotaviruses by polymerase chain reaction.Epidemiology and infection · 1994Article
- Rotaviruses belonging to the AU-1 genogroup recovered from Israeli infants with diarrhea.Archives of virology · 1994Article
- Serotype G6 human rotavirus sharing a conserved genetic constellation with natural reassortants between members of the bovine and AU-1 genogroups.Archives of virology · 1994Article
- Naturally occurring dual infection with human and bovine rotaviruses as suggested by the recovery of G1P8 and G1P5 rotaviruses from a single patient.Archives of virology · 1994Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rotavirus VP4 protein elicits the production of neutralizing antibodies and is known to play a role in inducing resistance to disease. At least five human rotavirus VP4 gene alleles have been described on the basis of antigenic polymorphism and/or nucleotide sequence differences. In the present study, we developed cDNA probes directed at the hyperdivergent region of the VP4 gene of the five described human rotavirus VP4 alleles (Wa, DS1, M37, AU228, and 69M) and used them in hybridization assays with human rotavirus strains from Latin America and Europe to determine the distribution of the VP4 gene alleles in nature. The Wa-like allele was detected most frequently, occurring in 57% of the 402 rotavirus strains tested, and the DS1-like allele was the next most common, occurring in 14% of the strains tested. The M37- and AU228-like alleles were detected in only 4 and 3% of the rotavirus strains tested, respectively, whereas the 69M-like VP4 gene allele was not detected. Several rotavirus strains from Europe did not react with any of the VP4 gene probes, although they did hybridize to a probe generated from a representative strain from the group. These data indicate the global distribution of various VP4 gene alleles and raise the possibility that other, unrecognized human VP4 alleles exist in nature because almost one-fourth of the strains could not be classified into any of the established VP4 groups.
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