ArticleNucleic acids research1993
An Alu element retroposition in two families with Huntington disease defines a new active Alu subfamily.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Alu mobile elements: from junk DNA to genomic gems.Scientifica · 2012Review
- Identification of a unique library of complex, but ordered, arrays of repetitive elements in the human genome and implication of their potential involvement in pathobiology.Experimental and molecular pathology · 2011Article
- A transcriptional analysis of the S1Bn (Brassica napus) family of SINE retroposons.Plant molecular biology · 1996Article
- Article
- A dimorphic Alu Sb-like insertion in COL3A1 is ethnic-specific.Journal of molecular evolution · 1996Article
- The role and amplification of the HS Alu subfamily founder gene.Journal of molecular evolution · 1996Article
- Genetic variation of recent Alu insertions in human populations.Journal of molecular evolution · 1996Article
- Standardized nomenclature for Alu repeats.Journal of molecular evolution · 1996Article
- The age of Alu subfamilies.Journal of molecular evolution · 1996Article
- Mosaic evolution of rodent B1 elements.Journal of molecular evolution · 1996Article
- A trinucleotide repeat-associated increase in the level of Alu RNA-binding protein occurred during the same period as the major Alu amplification that accompanied anthropoid evolution.Molecular and cellular biology · 1995Article
- Gene conversion as a secondary mechanism of short interspersed element (SINE) evolution.Molecular and cellular biology · 1995Article
- A young Alu subfamily amplified independently in human and African great apes lineages.Nucleic acids research · 1994Article
- Evolution of secondary structure in the family of 7SL-like RNAs.Journal of molecular evolution · 1994Article
- Species-specific amplification of tRNA-derived short interspersed repetitive elements (SINEs) by retroposition: a process of parasitization of entire genomes during the evolution of salmonids.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- An analysis of retroposition in plants based on a family of SINEs from Brassica napus.Journal of molecular evolution · 1994Article
- Evolutionary selection against change in many Alu repeat sequences interspersed through primate genomes.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA.Molecular and cellular biology · 1994Article
- Article
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7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alu repetitive elements represent the most common short interspersed elements (SINEs) found in primates, with an estimated 500,000 members in the haploid human genome. Considerable evidence has accumulated that these elements have dispersed in the genome by active transcription followed by retroposition, and that this process is ongoing. Sequence variation between the individual elements has lead to the hierarchical classification of Alu repeats into families and subfamilies. Young subfamilies that are still being actively transposed are of considerable interest, and the identification of one such subfamily (designated 'PV') has lead to the hypothesis that the most recent retroposition events are due to a single master Alu source gene. In the course of our search for the gene causing Huntington disease, we have detected an Alu retroposition event in two families. Sequence analysis demonstrates that this Alu element is not a member of the PV subfamily, but is similar to 5 other Alu elements in the GenBank database. Together, these Alu elements, all of which contain a 7 base-pair internal duplication, define a distinct subfamily, designated as the Sb2 subfamily, providing evidence for a second actively retroposing Alu source gene. These data provide support for multiple source genes for Alu retroposition in the human genome.
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