ArticleProceedings of the National Academy of Sciences of the United States of America1993
Two transmembrane signaling mechanisms control expression of the cAMP receptor gene CAR1 during Dictyostelium development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Transcriptomic Profiling of Adipose Tissues in Sujiang Pigs Reveals Candidate Genes Associated with Tissue-Specific Fat Deposition.Life (Basel, Switzerland) · 2026Article
- Lives in a gram of soil: linking life cycle biology to soil ecology.The ISME journal · 2026Review
- An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development ofFrontiers in cell and developmental biology · 2023Article
- From environmental sensing to developmental control: cognitive evolution in dictyostelid social amoebas.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Evolution of multicellularity in Dictyostelia.The International journal of developmental biology · 2019Review
- Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing.eLife · 2017Article
- Biological Activity of the Alternative Promoters of the Dictyostelium discoideum Adenylyl Cyclase A Gene.PloS one · 2016Article
- The Evolution of Aggregative Multicellularity and Cell-Cell Communication in the Dictyostelia.Journal of molecular biology · 2015Review
- The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium.Nature communications · 2015Article
- Mef2A, a homologue of animal Mef2 transcription factors, regulates cell differentiation in Dictyostelium discoideum.BMC developmental biology · 2013Article
- The Amoebozoa.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Evolution of self-organisation in Dictyostelia by adaptation of a non-selective phosphodiesterase and a matrix component for regulated cAMP degradation.Development (Cambridge, England) · 2012Article
- Evolution of developmental cyclic adenosine monophosphate signaling in the Dictyostelia from an amoebozoan stress response.Development, growth & differentiation · 2011Review
- Evolutionary crossroads in developmental biology: Dictyostelium discoideum.Development (Cambridge, England) · 2011Review
- Tomato polyphenol oxidase B is spatially and temporally regulated during development and in response to ethylene.Molecules (Basel, Switzerland) · 2011Article
- The Dictyostelium discoideum acaA gene is transcribed from alternative promoters during aggregation and multicellular development.PloS one · 2010Article
- Evolution of size and pattern in the social amoebas.BioEssays : news and reviews in molecular, cellular and developmental biology · 2007Review
- Treasure hunt in an amoeba: non-coding RNAs in Dictyostelium discoideum.Current genetics · 2007Review
- Evolutionary origin of cAMP-based chemoattraction in the social amoebae.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement.Genes & development · 2004Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dictyostelium discoideum is among the best characterized organisms for the study of receptor/guanine nucleotide binding protein-mediated control of differentiation. Dictyostelium grow unicellularly but form fully differentiated multicellular organisms through a developmental program regulated by secreted cAMP activating specific cell-surface receptors. Dictyostelium respond differentially to cAMP at different developmental stages. During early development, expression of certain genes is induced by low-level oscillations of extracellular cAMP. Later, continuous, high cAMP concentrations will promote expression of specific genes in multicellular structures. Here, we show that the cAMP receptor gene CAR1, which is essential for development, utilizes two promoters that are activated at distinct stages of development and respond to different extracellular cAMP conditions. One promoter is active with low-level oscillations of cAMP; exposure to high cAMP concentrations will repress this promoter and induce a second promoter. The CAR1 mRNAs are alternatively spliced but encode identical proteins. Thus, through differential sensitivity to its own ligand, cAMP, two promoters and alternative splicing regulate CAR1 expression during Dictyostelium development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.