ArticleThe Journal of clinical investigation1993
Contractile elements and myosin light chain phosphorylation in myometrial tissue from nonpregnant and pregnant women.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 113 citations in OpenAlex.
- Incidence and predictors of dystocia during the active first stage of labor among mothers at Debre Markos Comprehensive Specialized Hospital, Amhara, Northwest Ethiopia.BMC pregnancy and childbirth · 2025Article
- Integrated proteomics and metabolomics network analysis across different delivery modes in human pregnancy: a pilot study.BMC pregnancy and childbirth · 2024Article
- Perivascular Adipose Tissue and Uterine Artery Adaptations to Pregnancy.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways.Frontiers in endocrinology · 2022Review
- Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction.Journal of molecular cell biology · 2021Article
- The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.Frontiers in pharmacology · 2021Article
- Human Uterine Biopsy: Research Value and Common Pitfalls.International journal of reproductive medicine · 2020Review
- Gender differences in the regulation of MLCBiomedical reports · 2018Article
- Inhibition of actin polymerization by marine toxin pectenotoxin-2.The Journal of veterinary medical science · 2018Article
- Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects.BMC medical genomics · 2018Article
- Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy.Pflugers Archiv : European journal of physiology · 2017Article
- Article
- Human uterine lower segment myometrial cell and nuclear volume at term: influence of maternal age.Journal of anatomy · 2014Article
- Effect of estrogen on molecular and functional characteristics of the rodent vaginal muscularis.The journal of sexual medicine · 2013Article
- Development and validation of primary human myometrial cell culture models to study pregnancy and labour.BMC pregnancy and childbirth · 2013Article
- A close look at the contraction and relaxation of the myometrium; the role of calcium.Journal of the Turkish German Gynecological Association · 2013Review
- Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Phosphorylation of h1 calponin by PKC epsilon may contribute to facilitate the contraction of uterine myometrium in mice during pregnancy and labor.Reproductive biology and endocrinology : RB&E · 2012Article
- Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine.Neurogastroenterology and motility · 2012Article
- A molecular signature of an arrest of descent in human parturition.American journal of obstetrics and gynecology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Smooth muscle contraction is initiated primarily by an increase in intracellular Ca2+, Ca(2+)-dependent activation of myosin light chain kinase, and phosphorylation of myosin light chain. In this investigation, we identified pregnancy-associated alterations in myosin light chain phosphorylation, force of contraction, and content of contractile proteins in human myometrium. Steady-state levels of myosin light chain phosphorylation and contractile stress were correlated positively in both tissues, but the myometrial strips from pregnant women developed more stress at any given level of myosin light chain phosphorylation. During spontaneous contractions and during conditions that favor maximal generation of stress, the rate and extent of myosin light chain phosphorylation were attenuated in myometrial strips from pregnant women. The content of myosin and actin per milligram of protein and per tissue cross-sectional area was similar between myometrium of nonpregnant and pregnant women. Although cell size was significantly increased in tissues obtained from pregnant women, the amounts of contractile proteins per cellular cross-sectional area were similar. In addition, myosin light chain kinase and phosphatase activities were similar in the two tissues. The content of caldesmon was significantly increased in myometrium of pregnant women, whereas that of calponin (a smooth muscle-specific protein associated with the thin filaments) was not different. We conclude that adaptations of human myometrium during pregnancy include (a) cellular mechanisms that preclude the development of high levels of myosin light chain phosphorylation during contraction and (b) an increase in the stress generating capacity for any given level of myosin light chain phosphorylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.